Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.

OBJECTIVE: Colorectal cancer (CRC) is a major contributor to cancer mortality and morbidity. LIM kinase 2 (LIMK2) promotes tumour cell invasion and metastasis. The objectives of this study were to determine how LIMK2 expression is associated with CRC progression and patient outcome, and to use genet...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Lourenço, F, Munro, J, Brown, J, Cordero, J, Stefanatos, R, Strathdee, K, Orange, C, Feller, S, Sansom, O, Vidal, M, Murray, G, Olson, M
Format:	Journal article
Sprog:	English
Udgivet:	2014

Lignende værker

LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration
af: Rui Mao, et al.
Udgivet: (2019-07-01)

Keratinocyte migration in the developing eyelid requires LIMK2.
af: Dennis S Rice, et al.
Udgivet: (2012-01-01)

Structural Aspects of LIMK Regulation and Pharmacology
af: Deep Chatterjee, et al.
Udgivet: (2022-01-01)

LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features
af: Elodie Villalonga, et al.
Udgivet: (2023-03-01)

MiR-106a directly targets LIMK1 to inhibit proliferation and EMT of oral carcinoma cells
af: Bingxia Shi, et al.
Udgivet: (2019-03-01)

Role of LIMK1 in trafficking of Rab5 vesicles
af: Lee, Michelle Jing Qi
Udgivet: (2018)

LIMK1 regulates centrosome integrity and mitotic spindle positioning
af: Ou, Sirong
Udgivet: (2015)

Lessons from LIMK1 enzymology and their impact on inhibitor design
af: Salah, E, et al.
Udgivet: (2019)

LIMK1 activity regulates Rab5 endosome trafficking
af: Lee, Bernadette Jia Rong
Udgivet: (2018)

ROCK1 and LIMK2 interact in spread but not blebbing cancer cells.
af: Kerry F Shea, et al.
Udgivet: (2008-01-01)

Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes
af: Annie Cristhine Moraes Sousa-Squiavinato, et al.
Udgivet: (2021-01-01)

LMO3 promotes proliferation and metastasis of papillary thyroid carcinoma cells by regulating LIMK1-mediated cofilin and the β-catenin pathway
af: Ling Zeyi, et al.
Udgivet: (2022-03-01)

Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression
af: Gutierrez-Hartmann Arthur, et al.
Udgivet: (2011-06-01)

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways
af: Crompton, M, et al.
Udgivet: (2017)

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
af: Michael Crompton, et al.
Udgivet: (2017-08-01)

LIMK1/2 inhibitor LIMKi 3 suppresses porcine oocyte maturation
af: Ru-Xia Jia, et al.
Udgivet: (2016-10-01)

Limk2 mediates semaphorin signalling in cortical interneurons migrating through the subpallium
af: William D. Andrews, et al.
Udgivet: (2013-01-01)

Upregulation of LIMK1 Is Correlated With Poor Prognosis and Immune Infiltrates in Lung Adenocarcinoma
af: Guojun Lu, et al.
Udgivet: (2021-06-01)

Dorsal visual stream and LIMK1: hemideletion, haplotype, and enduring effects in children with Williams syndrome
af: J. Shane Kippenhan, et al.
Udgivet: (2023-08-01)

Transformed Epithelia Trigger Non-Tissue-Autonomous Tumor Suppressor Response by Adipocytes via Activation of Toll and Eiger/TNF Signaling
af: Federica Parisi, et al.
Udgivet: (2014-03-01)

Effects of miR-373 Inhibition on Glioblastoma Growth by Reducing Limk1 In Vitro
af: Tao Peng, et al.
Udgivet: (2020-01-01)

MiR-20a is upregulated in anaplastic thyroid cancer and targets LIMK1.
af: Yin Xiong, et al.
Udgivet: (2014-01-01)

The Nature of Diamino Linker and Halogen Bonding Define Selectivity of Pyrrolopyrimidine-Based LIMK1 Inhibitors
af: Daryl Ariawan, et al.
Udgivet: (2021-12-01)

NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2
af: Zhong Yuanping, et al.
Udgivet: (2023-04-01)

Tetramethylpyrazine ameliorates acute lung injury by regulating the Rac1/LIMK1 signaling pathway
af: Simin Min, et al.
Udgivet: (2023-01-01)

Обучение и забывание у Drosophila melanogaster при полиморфизме по гену limk1
af: Екатерина Сергеевна Заломаева, et al.
Udgivet: (2021-12-01)

LIMK1/2 are required for actin filament and cell junction assembly in porcine embryos developing
af: Jeongwoo Kwon, et al.
Udgivet: (2020-10-01)

Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.
af: Brady, S, et al.
Udgivet: (2009)

LIM domain kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
af: Mathea, S
Udgivet: (2018)

LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package
af: Bullock, A
Udgivet: (2018)

LIM Domain Kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
af: Mathea, S
Udgivet: (2018)

Modulation of the LIMK Pathway by Myricetin: A Protective Strategy Against Neurological Impairments in Spinal Cord Injury
af: Abhishek Roy, et al.
Udgivet: (2024-09-01)

Correction: Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents
Udgivet: (2014-01-01)

Correction: Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents.
Udgivet: (2014-01-01)

TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation
af: Heng, Yi-Wen., et al.
Udgivet: (2014)

Myocardial fibrosis induced by nonylphenol and its regulatory effect on the TGF-β1/LIMK1 signaling pathway
af: Guo, Mei, et al.
Udgivet: (2024)

Identification of LIMK1 as a biomarker in clear cell renal cell carcinoma: from data mining to validation
af: Yifei Li, et al.
Udgivet: (2025-03-01)

Myocardial fibrosis induced by nonylphenol and its regulatory effect on the TGF-β1/LIMK1 signaling pathway
af: Mei Guo, et al.
Udgivet: (2024-03-01)

Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo
af: Jiahang Sun, et al.
Udgivet: (2017-09-01)

Dasatinib Inhibits Lung Cancer Cell Growth and Patient Derived Tumor Growth in Mice by Targeting LIMK1
af: Man Zhang, et al.
Udgivet: (2020-12-01)