Treat-to-target in PsA: methods and necessity
With increasing recognition of the high burden and impact of psoriatic arthritis (PsA) and the growing number of therapeutic options, there has been an intensifying focus on treatment strategy in recent years. In 2015, the Tight Control of Psoriatic Arthritis study confirmed the clinical benefit of...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
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BMJ Publishing Group
2020
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| _version_ | 1826270511721611264 |
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| author | Dures, E Shepperd, S Mukherjee, S Robson, J Vlaev, I Walsh, N Coates, LC |
| author_facet | Dures, E Shepperd, S Mukherjee, S Robson, J Vlaev, I Walsh, N Coates, LC |
| author_sort | Dures, E |
| collection | OXFORD |
| description | With increasing recognition of the high burden and impact of psoriatic arthritis (PsA) and the growing number of therapeutic options, there has been an intensifying focus on treatment strategy in recent years. In 2015, the Tight Control of Psoriatic Arthritis study confirmed the clinical benefit of using a treat-to-target approach in PsA. This randomised controlled trial found benefits in both arthritis and psoriasis disease activity as well as lower disease impact reported by patients, although participants allocated to tight control experienced a higher rate of serious adverse events. European and international recommendations support the use of a treat-to-target approach in PsA and have offered specific advice on how to do this using outcomes such as the minimal disease activity criteria. However, implementation of this approach in routine practice is low, with real-world data highlighting undertreatment as a result. Recent qualitative work with physicians in the UK has helped researchers to understand the barriers to implementation of treat-to-target in PsA. We now need to address these barriers, provide education and support to non-specialist clinicians in routine practice, and aid the translation of optimal care to the clinic. |
| first_indexed | 2024-03-06T21:41:58Z |
| format | Journal article |
| id | oxford-uuid:48394728-9bfe-4fdf-8e14-64a0fa3ea714 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:41:58Z |
| publishDate | 2020 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:48394728-9bfe-4fdf-8e14-64a0fa3ea7142022-03-26T15:24:32ZTreat-to-target in PsA: methods and necessityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:48394728-9bfe-4fdf-8e14-64a0fa3ea714Symplectic ElementsBMJ Publishing Group2020Dures, EShepperd, SMukherjee, SRobson, JVlaev, IWalsh, NCoates, LCWith increasing recognition of the high burden and impact of psoriatic arthritis (PsA) and the growing number of therapeutic options, there has been an intensifying focus on treatment strategy in recent years. In 2015, the Tight Control of Psoriatic Arthritis study confirmed the clinical benefit of using a treat-to-target approach in PsA. This randomised controlled trial found benefits in both arthritis and psoriasis disease activity as well as lower disease impact reported by patients, although participants allocated to tight control experienced a higher rate of serious adverse events. European and international recommendations support the use of a treat-to-target approach in PsA and have offered specific advice on how to do this using outcomes such as the minimal disease activity criteria. However, implementation of this approach in routine practice is low, with real-world data highlighting undertreatment as a result. Recent qualitative work with physicians in the UK has helped researchers to understand the barriers to implementation of treat-to-target in PsA. We now need to address these barriers, provide education and support to non-specialist clinicians in routine practice, and aid the translation of optimal care to the clinic. |
| spellingShingle | Dures, E Shepperd, S Mukherjee, S Robson, J Vlaev, I Walsh, N Coates, LC Treat-to-target in PsA: methods and necessity |
| title | Treat-to-target in PsA: methods and necessity |
| title_full | Treat-to-target in PsA: methods and necessity |
| title_fullStr | Treat-to-target in PsA: methods and necessity |
| title_full_unstemmed | Treat-to-target in PsA: methods and necessity |
| title_short | Treat-to-target in PsA: methods and necessity |
| title_sort | treat to target in psa methods and necessity |
| work_keys_str_mv | AT durese treattotargetinpsamethodsandnecessity AT shepperds treattotargetinpsamethodsandnecessity AT mukherjees treattotargetinpsamethodsandnecessity AT robsonj treattotargetinpsamethodsandnecessity AT vlaevi treattotargetinpsamethodsandnecessity AT walshn treattotargetinpsamethodsandnecessity AT coateslc treattotargetinpsamethodsandnecessity |