Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats.

Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats.

Local adenoviral (Ad)-mediated gene transfer to the carotid artery of the stroke-prone spontaneously hypertensive rat (SHRSP) is successful in improving endothelial function. Here we explored the potential of systemic delivery of Ad encoding endothelial nitric oxide synthase (AdeNOS) to prevent elev...

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Detalles Bibliográficos
Autores principales: Miller, W, Brosnan, M, Graham, D, Nicol, C, Morecroft, I, Channon, K, Danilov, S, Reynolds, P, Baker, A, Dominiczak, A
Formato: Journal article
Lenguaje:English
Publicado: 2005

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