Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats.
Local adenoviral (Ad)-mediated gene transfer to the carotid artery of the stroke-prone spontaneously hypertensive rat (SHRSP) is successful in improving endothelial function. Here we explored the potential of systemic delivery of Ad encoding endothelial nitric oxide synthase (AdeNOS) to prevent elev...
主要な著者: | Miller, W, Brosnan, M, Graham, D, Nicol, C, Morecroft, I, Channon, K, Danilov, S, Reynolds, P, Baker, A, Dominiczak, A |
---|---|
フォーマット: | Journal article |
言語: | English |
出版事項: |
2005
|
類似資料
-
Targeted delivery of adenovirus expressing eNOS to the endothelium in vivo lowers blood pressure in hypertensive rats
著者:: Miller, W, 等
出版事項: (2004) -
Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats.
著者:: Brosnan, M, 等
出版事項: (2002) -
Sustained lowering of systolic blood pressure using an endothelial cell-targeted adenoviral vector
著者:: Miller, W, 等
出版事項: (2004) -
Endothelial targeting of adenoviral vectors expressing eNOS lowers blood pressure in a rat model of genetic hypertension
著者:: Miller, W, 等
出版事項: (2004) -
Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
著者:: Channon, K
出版事項: (2004)