African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

Polygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46) showed reduced performance in men with African genetic ancestry. We used a cross-validated search to identify single nucleotide polymorphisms (SNPs) that might improv...

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Autors principals: Karunamuni, RA, Huynh-Le, M-P, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, Lophatananon, A, Tangen, CM, Goodman, PJ, Thompson Jr, IM, Blot, WJ, Zheng, W, Kibel, AS, Drake, BF, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Park, JY, Lin, H-Y, Bensen, JT, Fontham, ETH, Mohler, JL, Taylor, JA, Multigner, L, Blanchet, P, Brureau, L, Romana, M, Leach, RJ, John, EM, Fowke, J, Bush, WS, Aldrich, M, Crawford, DC, Srivastava, S, Cullen, JC, Petrovics, G, Parent, M-É, Hu, JJ, Sanderson, M, Mills, IG, Andreassen, OA, Dale, AM, Seibert, TM
Altres autors: UKGPCS collaborators
Format: Journal article
Idioma:English
Publicat: Wiley 2020

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