African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

Polygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46) showed reduced performance in men with African genetic ancestry. We used a cross-validated search to identify single nucleotide polymorphisms (SNPs) that might improv...

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Главные авторы: Karunamuni, RA, Huynh-Le, M-P, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, Lophatananon, A, Tangen, CM, Goodman, PJ, Thompson Jr, IM, Blot, WJ, Zheng, W, Kibel, AS, Drake, BF, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Park, JY, Lin, H-Y, Bensen, JT, Fontham, ETH, Mohler, JL, Taylor, JA, Multigner, L, Blanchet, P, Brureau, L, Romana, M, Leach, RJ, John, EM, Fowke, J, Bush, WS, Aldrich, M, Crawford, DC, Srivastava, S, Cullen, JC, Petrovics, G, Parent, M-É, Hu, JJ, Sanderson, M, Mills, IG, Andreassen, OA, Dale, AM, Seibert, TM
Другие авторы: UKGPCS collaborators
Формат: Journal article
Язык:English
Опубликовано: Wiley 2020

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