African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

Polygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46) showed reduced performance in men with African genetic ancestry. We used a cross-validated search to identify single nucleotide polymorphisms (SNPs) that might improv...

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書目詳細資料
Main Authors: Karunamuni, RA, Huynh-Le, M-P, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, Lophatananon, A, Tangen, CM, Goodman, PJ, Thompson Jr, IM, Blot, WJ, Zheng, W, Kibel, AS, Drake, BF, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Park, JY, Lin, H-Y, Bensen, JT, Fontham, ETH, Mohler, JL, Taylor, JA, Multigner, L, Blanchet, P, Brureau, L, Romana, M, Leach, RJ, John, EM, Fowke, J, Bush, WS, Aldrich, M, Crawford, DC, Srivastava, S, Cullen, JC, Petrovics, G, Parent, M-É, Hu, JJ, Sanderson, M, Mills, IG, Andreassen, OA, Dale, AM, Seibert, TM
其他作者: UKGPCS collaborators
格式: Journal article
語言:English
出版: Wiley 2020

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