Advances in the 5q- syndrome.

Advances in the 5q- syndrome.

The 5q- syndrome is the most distinct of all the myelodysplastic syndromes with a clear genotype/phenotype relationship. The significant progress made during recent years has been based on the determination of the commonly deleted region and the demonstration of haploinsufficiency for the ribosomal...

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Bibliografiske detaljer
Main Authors:	Boultwood, J, Pellagatti, A, McKenzie, A, Wainscoat, J
Format:	Journal article
Sprog:	English
Udgivet:	2010

Lignende værker

5q- syndrome.
af: Boultwood, J, et al.
Udgivet: (2012)

RECENT ADVANCES IN THE 5Q- SYNDROME
af: Andrea Pellagatti, et al.
Udgivet: (2015-05-01)

Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome.
af: Boultwood, J, et al.
Udgivet: (2012)

The 5q-syndrome.
af: Boultwood, J, et al.
Udgivet: (1994)

Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome.
af: Pellagatti, A, et al.
Udgivet: (2010)

Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies.
af: Boultwood, J, et al.
Udgivet: (2013)

The 5q- syndrome.
af: Giagounidis, A, et al.
Udgivet: (2004)

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome.
af: Pellagatti, A, et al.
Udgivet: (2011)

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome
af: Pellagatti, A, et al.
Udgivet: (2011)

Gene expression profiling in 5q-syndrome and myelodysplastic syndromes.
af: Pellagatti, A, et al.
Udgivet: (2003)

MOLECULAR DELINEATION OF THE CRITICAL REGION OF THE 5Q-CHROMOSOME IN THE 5Q-SYNDROME
af: Boultwood, J, et al.
Udgivet: (1993)

The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome.
af: Fidler, C, et al.
Udgivet: (1999)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes with and without a del(5q)
af: Pellagatti, A, et al.
Udgivet: (2005)

Lenalidomide selectively inhibits in vitro growth of the malignant clone in myelodysplastic syndrome (MDS) patients with 5q deletion.
af: Jadersten, M, et al.
Udgivet: (2005)

Molecular mapping of uncharacteristically small 5q deletions in two patients with the 5q- syndrome: delineation of the critical region on 5q and identification of a 5q- breakpoint.
af: Boultwood, J, et al.
Udgivet: (1994)

MOLECULAR MAPPING OF UNCHARACTERISTICALLY SMALL 5Q DELETIONS IN 2 PATIENTS WITH THE 5Q- SYNDROME - DELINEATION OF THE CRITICAL REGION ON 5Q AND IDENTIFICATION OF A 5Q- BREAKPOINT
af: Boultwood, J, et al.
Udgivet: (1993)

Gene expression profiling in the myelodysplastic syndromes.
af: Pellagatti, A, et al.
Udgivet: (2005)

Effects of L-leucine in 5q-syndrome and other RPS14-deficient erythroblasts
af: Yip, B, et al.
Udgivet: (2012)

Effects of L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.
af: Yip, B, et al.
Udgivet: (2012)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes with and without a del(5q).
af: Pellagatti, A, et al.
Udgivet: (2004)

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression.
af: Jädersten, M, et al.
Udgivet: (2009)

SF3B1 mutant myelodysplastic syndrome: Recent advances
af: Pellagatti, A, et al.
Udgivet: (2020)

ISOLATION OF NOVEL CDNA CLONES MAPPING TO THE CRITICAL REGION OF THE 5Q-CHROMOSOME IN THE 5Q-SYNDROME
af: Boultwood, J, et al.
Udgivet: (1994)

Homozygous deletion of FMS in a patient with the 5q- syndrome.
af: Boultwood, J, et al.
Udgivet: (1990)

Narrowing and genomic annotation of the critical region of the 5q-syndrome.
af: Boultwood, J, et al.
Udgivet: (2000)

Gene expression profiling of CD34+ cells in patients with the 5q- syndrome.
af: Boultwood, J, et al.
Udgivet: (2007)

Haploinsufficiency of RPS14 in 5q- syndrome is associated with deregulation of ribosomal- and translation-related genes.
af: Pellagatti, A, et al.
Udgivet: (2008)

Physical mapping of the human ATX1 homologue (HAH1) to the critical region of the 5q- syndrome within 5q32, and immediately adjacent to the SPARC gene.
af: Boultwood, J, et al.
Udgivet: (2000)

Molecular analysis of the 5q-syndrome
af: Boultwood, J
Udgivet: (2007)

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.
af: Barlow, J, et al.
Udgivet: (2010)

Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes.
af: Fernandez-Mercado, M, et al.
Udgivet: (2013)

Combined immunophenotyping and FISH identifies the involvement of B-cells in 5q- syndrome.
af: Jaju, R, et al.
Udgivet: (2000)

Activation of the mTOR signaling pathway by L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.
af: Yip, B, et al.
Udgivet: (2013)

NRAS, FLT3 and TP53 mutations in patients with myelodysplastic syndrome and a del(5q).
af: Fidler, C, et al.
Udgivet: (2004)

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression
af: Martin Jädersten, et al.
Udgivet: (2009-12-01)

Activation of the mTOR signaling pathway by L-leucine in 5q-syndrome and other RPS14-deficient erythroblasts
af: Yip, B, et al.
Udgivet: (2013)

Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome.
af: Boultwood, J, et al.
Udgivet: (2002)

Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q- chromosome in some patients with the 5q- syndrome.
af: Boultwood, J, et al.
Udgivet: (1993)

Lenalidomide up-regulates SPARC and inhibits in vitro growth of the malignant clone in myelodysplastic syndrome patients with 5q deletion.
af: Pellagatti, A, et al.
Udgivet: (2006)

Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients.
af: Pellagatti, A, et al.
Udgivet: (2007)