Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage.

We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The first stage, with 272 microsatellite markers and 297 families, involved a sparse map covering 23 chromosomes at intervals of approximately 15 cM...

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Detaylı Bibliyografya
Asıl Yazarlar: Chapman, K, Mustafa, Z, Irven, C, Carr, A, Clipsham, K, Smith, A, Chitnavis, J, Sinsheimer, J, Bloomfield, V, McCartney, M, Cox, O, Cardon, L, Sykes, B, Loughlin, J
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 1999
Diğer Bilgiler
Özet:We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The first stage, with 272 microsatellite markers and 297 families, involved a sparse map covering 23 chromosomes at intervals of approximately 15 cM. Sixteen markers that showed evidence of linkage at nominal P