Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice
Choices rely on a transformation of sensory inputs into motor responses. Using invasive single neuron recordings, the evolution of a choice process has been tracked by projecting population neural responses into state spaces. Here, we develop an approach that allows us to recover similar trajectorie...
| Những tác giả chính: | , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
eLife Sciences Publications
2021
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| _version_ | 1826270554263388160 |
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| author | Takagi, Y Hunt, LT Woolrich, MW Behrens, TEJ Klein-Flügge, MC |
| author_facet | Takagi, Y Hunt, LT Woolrich, MW Behrens, TEJ Klein-Flügge, MC |
| author_sort | Takagi, Y |
| collection | OXFORD |
| description | Choices rely on a transformation of sensory inputs into motor responses. Using invasive single neuron recordings, the evolution of a choice process has been tracked by projecting population neural responses into state spaces. Here, we develop an approach that allows us to recover similar trajectories on a millisecond timescale in non-invasive human recordings. We selectively suppress activity related to three task-axes, relevant and irrelevant sensory inputs and response direction, in magnetoencephalography data acquired during context-dependent choices. Recordings from premotor cortex show a progression from processing sensory input to processing the response. In contrast to previous macaque recordings, information related to choice-irrelevant features is represented more weakly than choice-relevant sensory information. To test whether this mechanistic difference between species is caused by extensive over-training common in non-human primate studies, we trained humans on >20,000 trials of the task. Choice-irrelevant features were still weaker than relevant features in premotor cortex after over-training. |
| first_indexed | 2024-03-06T21:42:38Z |
| format | Journal article |
| id | oxford-uuid:487511c2-9c69-46b6-a067-e5310e8be185 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:42:38Z |
| publishDate | 2021 |
| publisher | eLife Sciences Publications |
| record_format | dspace |
| spelling | oxford-uuid:487511c2-9c69-46b6-a067-e5310e8be1852022-03-26T15:26:04ZAdapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choiceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:487511c2-9c69-46b6-a067-e5310e8be185EnglishSymplectic ElementseLife Sciences Publications2021Takagi, YHunt, LTWoolrich, MWBehrens, TEJKlein-Flügge, MCChoices rely on a transformation of sensory inputs into motor responses. Using invasive single neuron recordings, the evolution of a choice process has been tracked by projecting population neural responses into state spaces. Here, we develop an approach that allows us to recover similar trajectories on a millisecond timescale in non-invasive human recordings. We selectively suppress activity related to three task-axes, relevant and irrelevant sensory inputs and response direction, in magnetoencephalography data acquired during context-dependent choices. Recordings from premotor cortex show a progression from processing sensory input to processing the response. In contrast to previous macaque recordings, information related to choice-irrelevant features is represented more weakly than choice-relevant sensory information. To test whether this mechanistic difference between species is caused by extensive over-training common in non-human primate studies, we trained humans on >20,000 trials of the task. Choice-irrelevant features were still weaker than relevant features in premotor cortex after over-training. |
| spellingShingle | Takagi, Y Hunt, LT Woolrich, MW Behrens, TEJ Klein-Flügge, MC Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice |
| title | Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice |
| title_full | Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice |
| title_fullStr | Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice |
| title_full_unstemmed | Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice |
| title_short | Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice |
| title_sort | adapting non invasive human recordings along multiple task axes shows unfolding of spontaneous and over trained choice |
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