| Summary: | <p>This thesis documents the development of rhodium-catalyzed traceless chelation-controlled hydroacylation reactions for the synthesis of a variety of ketone products.</p> <p><strong>Chapter 1</strong> provides an overview of rhodium-catalyzed hydroacylation chemistry, focusing on the origin of chelation-controlled strategies and the benefits thereof.</p> <p><strong>Chapter 2</strong> describes a sequential reaction involving alkene hydroacylation, sulfide elimination and boronic acid conjugate addition, which affords products with the initial sulfide coordinating group replaced by a stereochemically defined aryl group.</p> <p><strong>Chapter 3</strong> demonstrates a sequential process involving alkyne hydroacylation, boronic acid conjugate addition and sulfide elimination, which provides enantioenriched β’-arylα,β-unsaturated ketones in a highly efficient and selective manner.</p> <p><strong>Chapter 4</strong> illustrates a versatile chelating group, triazene, for hydroacylation reactions. Subsequent functionalization of aromatic C-H bonds, promoted by the same chelating unit, offers highly substituted phenyl ketone products.</p> <p><strong>Chapter 5</strong> documents experimental procedures and data.</p>
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