Multiple sclerosis and lung cancer: an unexpected inverse association.
Multiple sclerosis is associated with a decreased risk of cancer. Smoking is a risk factor both for multiple sclerosis and lung cancer. We performed a meta-analysis on studies of cancer frequency in multiple sclerosis. Surprisingly, we found that the risk of lung cancer is reduced in multiple sclero...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797066496953810944 |
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| author | Handel, A Joseph, A Ramagopalan, S |
| author_facet | Handel, A Joseph, A Ramagopalan, S |
| author_sort | Handel, A |
| collection | OXFORD |
| description | Multiple sclerosis is associated with a decreased risk of cancer. Smoking is a risk factor both for multiple sclerosis and lung cancer. We performed a meta-analysis on studies of cancer frequency in multiple sclerosis. Surprisingly, we found that the risk of lung cancer is reduced in multiple sclerosis [odds ratio 0.67 (95% confidence interval 0.59-0.76) P < 0.00001]. Since this does not appear to be secondary to altered smoking behaviour, we hypothesise that this may be secondary to altered immune surveillance. |
| first_indexed | 2024-03-06T21:42:56Z |
| format | Journal article |
| id | oxford-uuid:489201fc-30e3-406d-8ef6-a7771655638b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:42:56Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:489201fc-30e3-406d-8ef6-a7771655638b2022-03-26T15:26:30ZMultiple sclerosis and lung cancer: an unexpected inverse association.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:489201fc-30e3-406d-8ef6-a7771655638bEnglishSymplectic Elements at Oxford2010Handel, AJoseph, ARamagopalan, SMultiple sclerosis is associated with a decreased risk of cancer. Smoking is a risk factor both for multiple sclerosis and lung cancer. We performed a meta-analysis on studies of cancer frequency in multiple sclerosis. Surprisingly, we found that the risk of lung cancer is reduced in multiple sclerosis [odds ratio 0.67 (95% confidence interval 0.59-0.76) P < 0.00001]. Since this does not appear to be secondary to altered smoking behaviour, we hypothesise that this may be secondary to altered immune surveillance. |
| spellingShingle | Handel, A Joseph, A Ramagopalan, S Multiple sclerosis and lung cancer: an unexpected inverse association. |
| title | Multiple sclerosis and lung cancer: an unexpected inverse association. |
| title_full | Multiple sclerosis and lung cancer: an unexpected inverse association. |
| title_fullStr | Multiple sclerosis and lung cancer: an unexpected inverse association. |
| title_full_unstemmed | Multiple sclerosis and lung cancer: an unexpected inverse association. |
| title_short | Multiple sclerosis and lung cancer: an unexpected inverse association. |
| title_sort | multiple sclerosis and lung cancer an unexpected inverse association |
| work_keys_str_mv | AT handela multiplesclerosisandlungcanceranunexpectedinverseassociation AT josepha multiplesclerosisandlungcanceranunexpectedinverseassociation AT ramagopalans multiplesclerosisandlungcanceranunexpectedinverseassociation |