Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study.
Amyotrophic lateral sclerosis (ALS) is a multi-system disorder. Mild cognitive deficits are present in a subgroup of non-demented patients with ALS. Detailed neuropsychological assessments reveal deficits of word retrieval including impairments on tests of verbal fluency and confrontation naming. Th...
| Príomhchruthaitheoirí: | , , , , , , |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2008
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| _version_ | 1826270574098251776 |
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| author | Wicks, P Turner, M Abrahams, S Hammers, A Brooks, D Leigh, P Goldstein, L |
| author_facet | Wicks, P Turner, M Abrahams, S Hammers, A Brooks, D Leigh, P Goldstein, L |
| author_sort | Wicks, P |
| collection | OXFORD |
| description | Amyotrophic lateral sclerosis (ALS) is a multi-system disorder. Mild cognitive deficits are present in a subgroup of non-demented patients with ALS. Detailed neuropsychological assessments reveal deficits of word retrieval including impairments on tests of verbal fluency and confrontation naming. The PET GABA(A) receptor ligand [11C]-flumazenil is a marker of neuronal dysfunction in ALS. This study used [11C]-flumazenil PET to identify correlations between cortical regions and impairments in word retrieval. Twelve patients with ALS underwent [11C]-flumazenil PET and neuropsychological assessment, including tests of written letter fluency and confrontation naming. Poorer performance on verbal fluency correlated with decreased [11C]-flumazenil binding in a region including the right inferior frontal gyrus, superior temporal gyrus, and anterior insula. Poorer performance on a test of confrontation naming correlated with decreased binding in the left middle frontal gyrus (extending to Broca's area) and left cuneus. This study indicates that [11C]-flumazenil PET can be used to help localize cortical regions associated with cognitive deficits in ALS. |
| first_indexed | 2024-03-06T21:42:58Z |
| format | Journal article |
| id | oxford-uuid:489478b8-496f-49dd-864c-ebc3bb8b7445 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:42:58Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:489478b8-496f-49dd-864c-ebc3bb8b74452022-03-26T15:26:35ZNeuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:489478b8-496f-49dd-864c-ebc3bb8b7445EnglishSymplectic Elements at Oxford2008Wicks, PTurner, MAbrahams, SHammers, ABrooks, DLeigh, PGoldstein, LAmyotrophic lateral sclerosis (ALS) is a multi-system disorder. Mild cognitive deficits are present in a subgroup of non-demented patients with ALS. Detailed neuropsychological assessments reveal deficits of word retrieval including impairments on tests of verbal fluency and confrontation naming. The PET GABA(A) receptor ligand [11C]-flumazenil is a marker of neuronal dysfunction in ALS. This study used [11C]-flumazenil PET to identify correlations between cortical regions and impairments in word retrieval. Twelve patients with ALS underwent [11C]-flumazenil PET and neuropsychological assessment, including tests of written letter fluency and confrontation naming. Poorer performance on verbal fluency correlated with decreased [11C]-flumazenil binding in a region including the right inferior frontal gyrus, superior temporal gyrus, and anterior insula. Poorer performance on a test of confrontation naming correlated with decreased binding in the left middle frontal gyrus (extending to Broca's area) and left cuneus. This study indicates that [11C]-flumazenil PET can be used to help localize cortical regions associated with cognitive deficits in ALS. |
| spellingShingle | Wicks, P Turner, M Abrahams, S Hammers, A Brooks, D Leigh, P Goldstein, L Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study. |
| title | Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study. |
| title_full | Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study. |
| title_fullStr | Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study. |
| title_full_unstemmed | Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study. |
| title_short | Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study. |
| title_sort | neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis an 11c flumazenil pet study |
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