Harnessing FOXP3+ regulatory T cells for transplantation tolerance.
Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes...
| 主要な著者: | , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
American Society for Clinical Investigation
2014
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| _version_ | 1826270580167409664 |
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| author | Waldmann, H Hilbrands, R Howie, D Cobbold, S |
| author_facet | Waldmann, H Hilbrands, R Howie, D Cobbold, S |
| author_sort | Waldmann, H |
| collection | OXFORD |
| description | Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression. |
| first_indexed | 2024-03-06T21:43:04Z |
| format | Journal article |
| id | oxford-uuid:489b681a-cfa7-47b1-9a0f-d69f48cea805 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:43:04Z |
| publishDate | 2014 |
| publisher | American Society for Clinical Investigation |
| record_format | dspace |
| spelling | oxford-uuid:489b681a-cfa7-47b1-9a0f-d69f48cea8052022-03-26T15:26:45ZHarnessing FOXP3+ regulatory T cells for transplantation tolerance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:489b681a-cfa7-47b1-9a0f-d69f48cea805EnglishSymplectic Elements at OxfordAmerican Society for Clinical Investigation2014Waldmann, HHilbrands, RHowie, DCobbold, SEarly demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression. |
| spellingShingle | Waldmann, H Hilbrands, R Howie, D Cobbold, S Harnessing FOXP3+ regulatory T cells for transplantation tolerance. |
| title | Harnessing FOXP3+ regulatory T cells for transplantation tolerance. |
| title_full | Harnessing FOXP3+ regulatory T cells for transplantation tolerance. |
| title_fullStr | Harnessing FOXP3+ regulatory T cells for transplantation tolerance. |
| title_full_unstemmed | Harnessing FOXP3+ regulatory T cells for transplantation tolerance. |
| title_short | Harnessing FOXP3+ regulatory T cells for transplantation tolerance. |
| title_sort | harnessing foxp3 regulatory t cells for transplantation tolerance |
| work_keys_str_mv | AT waldmannh harnessingfoxp3regulatorytcellsfortransplantationtolerance AT hilbrandsr harnessingfoxp3regulatorytcellsfortransplantationtolerance AT howied harnessingfoxp3regulatorytcellsfortransplantationtolerance AT cobbolds harnessingfoxp3regulatorytcellsfortransplantationtolerance |