Hepatic hepcidin/intestinal HIF-2a axis maintains iron absorption during iron deficiency and overload
Iron-related disorders are among the most prevalent diseases worldwide. Systemic iron homeostasis requires hepcidin, a hepatic-derived hormone that controls iron mobilization through its molecular target, ferroportin (FPN), the only known mammalian iron exporter. This pathway is perturbed in disease...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Published: |
American Society for Clinical Investigation
2018
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