Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.

Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.

The pH-sensitive renal potassium channel Kir1.1 is important for K+ homeostasis. Disruption of the pH-sensing mechanism causes type II Bartter syndrome. The pH sensor is thought to be an anomalously titrated lysine residue (K80) that interacts with two arginine residues as part of an 'RKR triad...

Full description

Bibliographic Details
Main Authors:	Rapedius, M, Haider, S, Browne, K, Shang, L, Sansom, M, Baukrowitz, T, Tucker, S
Format:	Journal article
Language:	English
Published:	2006

Similar Items

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.
by: Rapedius, M, et al.
Published: (2007)

Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.
by: Rapedius, M, et al.
Published: (2007)

Conformational rearrangements during PIP2 gating in Kir channels
by: Rapedius, M, et al.
Published: (2007)

Cystic fibrosis transmembrane conductance regulator-dependent up-regulation of Kir1.1 (ROMK) renal K+ channels by the epithelial sodium channel.
by: Konstas, A, et al.
Published: (2002)

Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel.
by: Konstas, A, et al.
Published: (2002)

Insights into the structural nature of the transition state in the Kir channel gating pathway.
by: Fowler, P, et al.
Published: (2014)

Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1.
by: Pessia, M, et al.
Published: (2001)

A Structural Model of a Kir Channel in the Open State Derived from Mutagenic Scanning of the Pore Gating Energetics
by: Bollepalli, M, et al.
Published: (2010)

Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.
by: Paynter, J, et al.
Published: (2010)

Random mutagenesis screening indicates the absence of a separate H+-sensor in the pH-sensitive Kir channels
by: Paynter, J, et al.
Published: (2010)

Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.
by: Paynter, J, et al.
Published: (2010)

Complementary computational and experimental evaluation of missense variants in the ROMK potassium channel.
by: Luca Ponzoni, et al.
Published: (2020-04-01)

Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.
by: Casamassima, M, et al.
Published: (2003)

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.
by: Shang, L, et al.
Published: (2008)

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.
by: Haider, S, et al.
Published: (2007)

Functional characterisation of missense variations in the Kir4.1 potassium channel (KCNJ10) associated with seizure susceptibility.
by: Shang, L, et al.
Published: (2005)

Identification of mutations in Kir5.1 which affect time-dependent activation of heteromeric Kir4.1/Kir5.1 potassium channels
by: Tucker, S, et al.
Published: (2002)

Crystal structure of the potassium channel KirBac1.1 in the closed state.
by: Kuo, A, et al.
Published: (2003)

Structural and thermodynamic characterization of the gating pathway in a K+ channel
by: Bollepalli, M, et al.
Published: (2014)

pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia.
by: Tucker, S, et al.
Published: (2000)

Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.
by: Konstas, A, et al.
Published: (2003)

The effect of high-dietary K+ (HK) on Kir4.1/Kir5.1 and ROMK in the distal convoluted tubule (DCT) is not affected by gender and Cl− content of the diet
by: Xin-Xin Meng, et al.
Published: (2022-11-01)

Genome mining yields putative disease-associated ROMK variants with distinct defects.
by: Nga H Nguyen, et al.
Published: (2023-11-01)

Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.
by: Rapedius, M, et al.
Published: (2005)

Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis.
by: Shang, L, et al.
Published: (2009)

State-dependent network connectivity determines gating in a K+ channel.
by: Bollepalli, M, et al.
Published: (2014)

Differential expression of the inwardly-rectifying K-channel ROMK1 in rat brain.
by: Kenna, S, et al.
Published: (1994)

Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.
by: Zubcevic, L, et al.
Published: (2014)

A novel mechanism of voltage sensing and gating in K2P potassium channels
by: Schewe, M, et al.
Published: (2014)

A Novel Mechanism of Voltage Sensing and Gating in K2P Potassium Channels
by: Schewe, M, et al.
Published: (2014)

A novel mechanism of voltage sensing and gating in K2P potassium channels
by: Rapedius, M, et al.
Published: (2014)

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
by: Haider, S, et al.
Published: (2005)

Differential pH sensitivity of Kir4.1 and Kir4.2 and their modulation by heteropolymerisation with Kir5.1
by: Pessia, M, et al.
Published: (2001)

Autoantibodies to Potassium Channel KIR4.1 in Multiple Sclerosis
by: Raphael eSchneider
Published: (2013-09-01)

Pharmacological Characterization of a Recombinant Mitochondrial ROMK2 Potassium Channel Expressed in Bacteria and Reconstituted in Planar Lipid Bilayers
by: Milena Krajewska, et al.
Published: (2023-03-01)

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating
by: Bavro, V, et al.
Published: (2012)

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.
by: Bavro, V, et al.
Published: (2012)

A phenylalanine at the extracellular side of Kir1.1 facilitates potassium permeation
by: Henry Sackin, et al.
Published: (2024-12-01)

SPAK and OSR1 Dependent Down-Regulation of Murine Renal Outer Medullary K+ Channel ROMK1
by: Bernat Elvira, et al.
Published: (2014-09-01)

Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels
by: Duncan, AL, et al.
Published: (2020)