Targeting triglyceride/fatty acid cycling in β-cells as a therapy for augmenting glucose-stimulated insulin secretion.
Insulin secretion from pancreatic β-cells is triggered by signals arising from the metabolism of glucose and acting through separate initiation and amplification pathways. Despite decades of investigation, crucial details of this mechanism remain poorly understood, especially those relating to the a...
Những tác giả chính: | Cantley, J, Biden, T |
---|---|
Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
2010
|
Những quyển sách tương tự
-
Deletion of protein kinase C epsilon in mice enhances glucose stimulated insulin secretion following lipid exposure by up-regulation of the amplifying pathways of insulin secretion
Bằng: Cantley, J, et al.
Được phát hành: (2008) -
Deletion of the Cited2 gene in beta cells causes impaired insulin secretion and glucose intolerance in mice
Bằng: Cantley, J, et al.
Được phát hành: (2011) -
Deletion of PKC Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse -Cells
Bằng: Cantley, J, et al.
Được phát hành: (2009) -
Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.
Bằng: Pearson, G, et al.
Được phát hành: (2014) -
Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
Bằng: Petr Ježek, et al.
Được phát hành: (2018-06-01)