Synthesis and gelation properties of poly(2-alkyl-2-oxazoline) based thermo-gels

A series of new thermo-gelling polymers based on thermo-responsive poly(2-alkyl-2-oxazoline)s has been prepared by grafting different poly(2-alkyl-2-oxazolines) onto a polar carboxymethylcellulose backbone. Thermo-reversible gelation is observed at low concentrations (less than 5%...

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Bibliographic Details
Main Authors: Aarts, D, Fisher, A, Schollick, J, Grossel, M
Format: Journal article
Published: Royal Society of Chemistry 2016
Description
Summary:A series of new thermo-gelling polymers based on thermo-responsive poly(2-alkyl-2-oxazoline)s has been prepared by grafting different poly(2-alkyl-2-oxazolines) onto a polar carboxymethylcellulose backbone. Thermo-reversible gelation is observed at low concentrations (less than 5% by weight of thermo-gelling polymer).Rheology reveals that these polymers show tuneable gelation temperatures, which vary with con centration and poly(2-oxazoline) composition. This allows the gelation point to be adjusted to biologically relevant temperatures, offering a novel material with potential applications in areas such as drug delivery and tissue engineering.