Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria.
Cerebrospinal-fluid (CSF) lactate concentrations were elevated in all but 1 of 45 patients with cerebral malaria. They were significantly higher in patients who died (9.0 +/- 5.3 mmol/l, mean +/- SD) than in survivors (3.4 +/- 1.1 mmol/l, p = 0.0002) and had returned to normal values in each of 9 pa...
| Main Authors: | , , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
1985
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| _version_ | 1826270603467816960 |
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| author | White, N Warrell, D Looareesuwan, S Chanthavanich, P Phillips, R Pongpaew, P |
| author_facet | White, N Warrell, D Looareesuwan, S Chanthavanich, P Phillips, R Pongpaew, P |
| author_sort | White, N |
| collection | OXFORD |
| description | Cerebrospinal-fluid (CSF) lactate concentrations were elevated in all but 1 of 45 patients with cerebral malaria. They were significantly higher in patients who died (9.0 +/- 5.3 mmol/l, mean +/- SD) than in survivors (3.4 +/- 1.1 mmol/l, p = 0.0002) and had returned to normal values in each of 9 patients studied after recovery of consciousness. There was a significant negative correlation between CSF lactate and CSF glucose. All 11 patients with CSF lactate concentrations above 6 mmol/l died. CSF lactate is thus an important prognostic indicator in cerebral malaria and these findings suggest that hypoxia contributes to the pathogenesis of this disorder. |
| first_indexed | 2024-03-06T21:43:26Z |
| format | Journal article |
| id | oxford-uuid:48bacf2c-d972-43da-bee3-ff8dc0752eba |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:43:26Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:48bacf2c-d972-43da-bee3-ff8dc0752eba2022-03-26T15:27:28ZPathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:48bacf2c-d972-43da-bee3-ff8dc0752ebaEnglishSymplectic Elements at Oxford1985White, NWarrell, DLooareesuwan, SChanthavanich, PPhillips, RPongpaew, PCerebrospinal-fluid (CSF) lactate concentrations were elevated in all but 1 of 45 patients with cerebral malaria. They were significantly higher in patients who died (9.0 +/- 5.3 mmol/l, mean +/- SD) than in survivors (3.4 +/- 1.1 mmol/l, p = 0.0002) and had returned to normal values in each of 9 patients studied after recovery of consciousness. There was a significant negative correlation between CSF lactate and CSF glucose. All 11 patients with CSF lactate concentrations above 6 mmol/l died. CSF lactate is thus an important prognostic indicator in cerebral malaria and these findings suggest that hypoxia contributes to the pathogenesis of this disorder. |
| spellingShingle | White, N Warrell, D Looareesuwan, S Chanthavanich, P Phillips, R Pongpaew, P Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria. |
| title | Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria. |
| title_full | Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria. |
| title_fullStr | Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria. |
| title_full_unstemmed | Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria. |
| title_short | Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria. |
| title_sort | pathophysiological and prognostic significance of cerebrospinal fluid lactate in cerebral malaria |
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