Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response

Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response

Protein arginine methyltransferase (PRMT) 5 is over-expressed in a variety of cancers and the master transcription regulator E2F1 is an important methylation target. We have explored the role of PRMT5 and E2F1 in regulating the non-coding genome and report here a striking effect on long non-coding (...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Barczak, W, Carr, SM, Liu, G, Munro, S, Nicastri, A, Lee, LN, Hutchings, C, Ternette, N, Klenerman, P, Kanapin, A, Samsonova, A, La Thangue, NB
Format:	Journal article
Sprache:	English
Veröffentlicht:	Springer Nature 2023

Ähnliche Einträge

Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response
von: Wojciech Barczak, et al.
Veröffentlicht: (2023-02-01)

Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control
von: Roworth, A, et al.
Veröffentlicht: (2019)

Sustained cancer‐relevant alternative RNA splicing events driven by PRMT5 in high‐risk neuroblastoma
von: Bate‐Eya, LT, et al.
Veröffentlicht: (2024)

Lysine methylation regulates the pRb tumour suppressor protein.
von: Munro, S, et al.
Veröffentlicht: (2010)

Diversity within the pRb pathway: is there a code of conduct?
von: Munro, S, et al.
Veröffentlicht: (2012)

The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity
von: Liu, G, et al.
Veröffentlicht: (2023)

The Choice of HLA-Associated Peptide Enrichment and Purification Strategy Affects Peptide Yields and Creates a Bias in Detected Sequence Repertoire
von: Nicastri, A, et al.
Veröffentlicht: (2020)

Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein
von: Carr, S, et al.
Veröffentlicht: (2017)

Elucidation of the signatures of proteasome-catalysed peptide splicing
von: Paes, W, et al.
Veröffentlicht: (2020)

Lysine methylation and the regulation of p53.
von: Carr, S, et al.
Veröffentlicht: (2012)

Corrigendum: Elucidation of the Signatures of Proteasome-Catalysed Peptide Splicing
von: Wayne Paes, et al.
Veröffentlicht: (2021-09-01)

Sustained cancer‐relevant alternative RNA splicing events driven by PRMT5 in high‐risk neuroblastoma
von: Laurel Tabe Bate‐Eya, et al.
Veröffentlicht: (2025-03-01)

Discrimination between human leukocyte antigen class I-bound and co-purified HIV-derived peptides in immunopeptidomics workflows
von: Partridge, T, et al.
Veröffentlicht: (2018)

An account of Fusarium wilt resistance in flax Linum usitatissimum: The disease severity data
von: Tatyana Rozhmina, et al.
Veröffentlicht: (2022-04-01)

Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows
von: Thomas Partridge, et al.
Veröffentlicht: (2018-04-01)

Tumour immunogenicity goes with the (mitochondrial electron) flow
von: Asma Ahmed, et al.
Veröffentlicht: (2024-05-01)

IMMUNOGENIC HIV VARIANT PEPTIDES THAT BIND TO HLA-B8 BUT FAIL TO STIMULATE CYTOTOXIC T-LYMPHOCYTE RESPONSES
von: Mcadam, S, et al.
Veröffentlicht: (1995)

NEDDylation regulates E2F-1-dependent transcription.
von: Loftus, S, et al.
Veröffentlicht: (2012)

A comprehensive dataset of flax (Linum uitatissimum L.) phenotypes
von: Tatyana Rozhmina, et al.
Veröffentlicht: (2021-08-01)

Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity
von: Backlund, Coralie M, et al.
Veröffentlicht: (2023)

Contribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection
von: Paes, W, et al.
Veröffentlicht: (2019)

Peptide Aggregation Induced Immunogenic Rupture (PAIIR)
von: Gokhan Gunay, et al.
Veröffentlicht: (2022-07-01)

Reciprocal Inhibition of Immunogenic Performance in Mice of Two Potent DNA Immunogens Targeting HCV-Related Liver Cancer
von: Juris Jansons, et al.
Veröffentlicht: (2021-05-01)

Stochastic Effects in Retrotransposon Dynamics Revealed by Modeling under Competition for Cellular Resources
von: Sergey Pavlov, et al.
Veröffentlicht: (2021-11-01)

Mass spectrometry–based identification of MHC-bound peptides for immunopeptidomics
von: Purcell, A, et al.
Veröffentlicht: (2019)

Techniques for Theoretical Prediction of Immunogenic Peptides
von: Robert Friedman
Veröffentlicht: (2024-03-01)

Structural and thermodynamic approach to peptide immunogenicity.
von: Carlos J Camacho, et al.
Veröffentlicht: (2008-11-01)

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.
von: Carr, S, et al.
Veröffentlicht: (2011)

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.
von: Carr, S, et al.
Veröffentlicht: (2011)

Immunogenic HIV variant peptides that bind to HLA-B8 can fail to stimulate cytotoxic T lymphocyte responses.
von: McAdam, S, et al.
Veröffentlicht: (1995)

Inhibition of UBA6 by inosine augments tumour immunogenicity and responses
von: Lei Zhang, et al.
Veröffentlicht: (2022-09-01)

The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila
von: Jean-Philippe Parvy, et al.
Veröffentlicht: (2019-07-01)

Application of Cytokines and Synthetic Peptides for Increase in Immunogenicity of Melioidosis Antigens
von: O. B. Dem’Yanova, et al.
Veröffentlicht: (2014-09-01)

The tumour hypoxia induced non-coding transcriptome.
von: Choudhry, H, et al.
Veröffentlicht: (2016)

IIIVmrMLM Provides New Insights into the Genetic Basis of the Agronomic Trait Variation in Chickpea
von: Maria Duk, et al.
Veröffentlicht: (2024-08-01)

A collection of read depth profiles at structural variant breakpoints
von: Igor Bezdvornykh, et al.
Veröffentlicht: (2023-04-01)

Taipan Natriuretic Peptides Are Potent and Selective Agonists for the Natriuretic Peptide Receptor A
von: Simone Vink, et al.
Veröffentlicht: (2023-03-01)

TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases
von: Juliane Totzke, et al.
Veröffentlicht: (2020-09-01)

The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity
von: Geng Liu, et al.
Veröffentlicht: (2023-01-01)

Linking H1 with chromatin and growth control.
von: Munro, S, et al.
Veröffentlicht: (2017)