Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response

Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response

Protein arginine methyltransferase (PRMT) 5 is over-expressed in a variety of cancers and the master transcription regulator E2F1 is an important methylation target. We have explored the role of PRMT5 and E2F1 in regulating the non-coding genome and report here a striking effect on long non-coding (...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Barczak, W, Carr, SM, Liu, G, Munro, S, Nicastri, A, Lee, LN, Hutchings, C, Ternette, N, Klenerman, P, Kanapin, A, Samsonova, A, La Thangue, NB
Format:	Journal article
Język:	English
Wydane:	Springer Nature 2023

Podobne zapisy

Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response
od: Wojciech Barczak, i wsp.
Wydane: (2023-02-01)

Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control
od: Roworth, A, i wsp.
Wydane: (2019)

Sustained cancer‐relevant alternative RNA splicing events driven by PRMT5 in high‐risk neuroblastoma
od: Bate‐Eya, LT, i wsp.
Wydane: (2024)

Lysine methylation regulates the pRb tumour suppressor protein.
od: Munro, S, i wsp.
Wydane: (2010)

The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity
od: Liu, G, i wsp.
Wydane: (2023)

Diversity within the pRb pathway: is there a code of conduct?
od: Munro, S, i wsp.
Wydane: (2012)

The Choice of HLA-Associated Peptide Enrichment and Purification Strategy Affects Peptide Yields and Creates a Bias in Detected Sequence Repertoire
od: Nicastri, A, i wsp.
Wydane: (2020)

Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein
od: Carr, S, i wsp.
Wydane: (2017)

Elucidation of the signatures of proteasome-catalysed peptide splicing
od: Paes, W, i wsp.
Wydane: (2020)

Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity
od: Backlund, Coralie M, i wsp.
Wydane: (2023)

Lysine methylation and the regulation of p53.
od: Carr, S, i wsp.
Wydane: (2012)

Corrigendum: Elucidation of the Signatures of Proteasome-Catalysed Peptide Splicing
od: Wayne Paes, i wsp.
Wydane: (2021-09-01)

Sustained cancer‐relevant alternative RNA splicing events driven by PRMT5 in high‐risk neuroblastoma
od: Laurel Tabe Bate‐Eya, i wsp.
Wydane: (2025-03-01)

The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila
od: Jean-Philippe Parvy, i wsp.
Wydane: (2019-07-01)

Discrimination between human leukocyte antigen class I-bound and co-purified HIV-derived peptides in immunopeptidomics workflows
od: Partridge, T, i wsp.
Wydane: (2018)

An account of Fusarium wilt resistance in flax Linum usitatissimum: The disease severity data
od: Tatyana Rozhmina, i wsp.
Wydane: (2022-04-01)

Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows
od: Thomas Partridge, i wsp.
Wydane: (2018-04-01)

Tumour immunogenicity goes with the (mitochondrial electron) flow
od: Asma Ahmed, i wsp.
Wydane: (2024-05-01)

IMMUNOGENIC HIV VARIANT PEPTIDES THAT BIND TO HLA-B8 BUT FAIL TO STIMULATE CYTOTOXIC T-LYMPHOCYTE RESPONSES
od: Mcadam, S, i wsp.
Wydane: (1995)

NEDDylation regulates E2F-1-dependent transcription.
od: Loftus, S, i wsp.
Wydane: (2012)

A comprehensive dataset of flax (Linum uitatissimum L.) phenotypes
od: Tatyana Rozhmina, i wsp.
Wydane: (2021-08-01)

Contribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection
od: Paes, W, i wsp.
Wydane: (2019)

Peptide Aggregation Induced Immunogenic Rupture (PAIIR)
od: Gokhan Gunay, i wsp.
Wydane: (2022-07-01)

Reciprocal Inhibition of Immunogenic Performance in Mice of Two Potent DNA Immunogens Targeting HCV-Related Liver Cancer
od: Juris Jansons, i wsp.
Wydane: (2021-05-01)

Stochastic Effects in Retrotransposon Dynamics Revealed by Modeling under Competition for Cellular Resources
od: Sergey Pavlov, i wsp.
Wydane: (2021-11-01)

Mass spectrometry–based identification of MHC-bound peptides for immunopeptidomics
od: Purcell, A, i wsp.
Wydane: (2019)

Techniques for Theoretical Prediction of Immunogenic Peptides
od: Robert Friedman
Wydane: (2024-03-01)

Structural and thermodynamic approach to peptide immunogenicity.
od: Carlos J Camacho, i wsp.
Wydane: (2008-11-01)

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.
od: Carr, S, i wsp.
Wydane: (2011)

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.
od: Carr, S, i wsp.
Wydane: (2011)

Immunogenic HIV variant peptides that bind to HLA-B8 can fail to stimulate cytotoxic T lymphocyte responses.
od: McAdam, S, i wsp.
Wydane: (1995)

Inhibition of UBA6 by inosine augments tumour immunogenicity and responses
od: Lei Zhang, i wsp.
Wydane: (2022-09-01)

Application of Cytokines and Synthetic Peptides for Increase in Immunogenicity of Melioidosis Antigens
od: O. B. Dem’Yanova, i wsp.
Wydane: (2014-09-01)

Immunogenic self-peptides - the great unknowns in autoimmunity: Identifying T-cell epitopes driving the autoimmune response in autoimmune diseases
od: Jörg Christoph Prinz
Wydane: (2023-01-01)

IIIVmrMLM Provides New Insights into the Genetic Basis of the Agronomic Trait Variation in Chickpea
od: Maria Duk, i wsp.
Wydane: (2024-08-01)

A collection of read depth profiles at structural variant breakpoints
od: Igor Bezdvornykh, i wsp.
Wydane: (2023-04-01)

Taipan Natriuretic Peptides Are Potent and Selective Agonists for the Natriuretic Peptide Receptor A
od: Simone Vink, i wsp.
Wydane: (2023-03-01)

The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity
od: Geng Liu, i wsp.
Wydane: (2023-01-01)

TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases
od: Juliane Totzke, i wsp.
Wydane: (2020-09-01)

Linking H1 with chromatin and growth control.
od: Munro, S, i wsp.
Wydane: (2017)