The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

PURPOSE: Drusen, which are defined clinically as yellowish white spots in the outer retina, are cardinal features of age-related macular degeneration (AMD). Ccl2-knockout (Ccl2(-/-)) mice have been reported to develop drusen and phenotypic features similar to AMD, including an increased susceptibili...

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Бібліографічні деталі
Автори: Luhmann, U, Robbie, S, Munro, P, Barker, SE, Duran, Y, Luong, V, Fitzke, F, Bainbridge, J, Ali, R, Maclaren, R
Формат: Journal article
Мова:English
Опубліковано: 2009

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