| Summary: | The traditional goal of quantitative analytics is to find simple, transparent models that generate explainable insights. In recent years, large-scale data acquisition enabled, for instance, by brain scanning and genomic profiling with microarray-type techniques, has prompted a wave of statistical inventions and innovative applications. Here we review some of the main trends in learning from ‘big data’ and provide examples from imaging neuroscience. Some main messages we find are that modern analysis approaches (1) tame complex data with parameter regularization and dimensionality-reduction strategies, (2) are increasingly backed up by empirical model validations rather than justified by mathematical proofs, (3) will compare against and build on open data and consortium repositories, as well as (4) often embrace more elaborate, less interpretable models to maximize prediction accuracy.
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