Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis.

Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis.

Nephrolithiasis (kidney stones) affects 5-10% of adults and is most commonly associated with hypercalciuria, which may be due to monogenic renal tubular disorders. One such hypercalciuric disorder is Dent's disease, which is characterized by renal proximal tubular defects that include low molec...

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מידע ביבליוגרפי
Main Authors:	Wang, S, Devuyst, O, Courtoy, P, Wang, X, Wang, H, Wang, Y, Thakker, R, Guggino, S, Guggino, W
פורמט:	Journal article
שפה:	English
יצא לאור:	2000

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