Markers associated with synovial inflammation can identify women at high risk of developing painful radiographic knee osteoarthritis: a prospective community based cohort

Markers associated with synovial inflammation can identify women at high risk of developing painful radiographic knee osteoarthritis: a prospective community based cohort

<p>Knee osteoarthritis (KOA) is commonly defined by radiographic changes and knee pain. KOA has a multifactorial aetiology, but there are several well-recognised strong risk factors for the incidence of KOA. These include age, sex, body mass index (BMI), previous injuries, bone density, smokin...

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Библиографические подробности
Главные авторы: Kluzek, W, Thudium, C, Bay-Jensen, A, Karsdal, M, Sanchez, M, Cairns, G, Spector, T, Hart, D, Cooper, C, Newton, J, Arden, N
Формат: Conference item
Опубликовано: Elsevier 2018
Описание
Итог:<p>Knee osteoarthritis (KOA) is commonly defined by radiographic changes and knee pain. KOA has a multifactorial aetiology, but there are several well-recognised strong risk factors for the incidence of KOA. These include age, sex, body mass index (BMI), previous injuries, bone density, smoking and pre-existing hand osteoarthritis (HOA). Factors associated with mild systemic and synovial inflammation are potential markers for KOA incidence.</p> <br/> <p>The hypothesis for this research was that selected markers associated with synovial inflammation and/or variables linked with metabolic syndrome (MetS) are prognostic for KOA incidence. Self-reported knee stiffness, serum markers associated with knee synovitis, and variables associated with MetS were selected as potential risk factors for KOA incident.</p>

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