Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalysed reactions. Isotopically-labelled L-serine is often used to monitor the activity of the first enzyme in sphingolipid biosynthesis, serine palmitoyltrans...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Harrison, PJ, Gable, K, Somashekarappa, N, Kelly, V, Clarke, DJ, Naismith, JH, Dunn, TM, Campopiano, DJ
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	American Society for Biochemistry and Molecular Biology 2019

Những quyển sách tương tự

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase
Bằng: Peter J. Harrison, et al.
Được phát hành: (2019-05-01)

Erratum: Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase
Bằng: Peter J. Harrison, et al.
Được phát hành: (2019-08-01)

An improved method to determine serine palmitoyltransferase activity
Bằng: Markus F. Ru¨tti, et al.
Được phát hành: (2009-06-01)

Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
Bằng: Yuancai Xiang, et al.
Được phát hành: (2021-03-01)

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis
Bằng: Deanna Siow, et al.
Được phát hành: (2015-04-01)

Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine.
Bằng: R D Williams, et al.
Được phát hành: (1987-12-01)

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition
Bằng: Sandra Hoefgen, et al.
Được phát hành: (2022-10-01)

Specialized acyl carrier protein used by serine palmitoyltransferase to synthesize sphingolipids in Rhodobacteria
Bằng: Jonathan Padilla-Gómez, et al.
Được phát hành: (2022-08-01)

Serine Palmitoyltransferase, the First Step Enzyme in Sphingolipid Biosynthesis, Is Involved in Nonhost Resistance
Bằng: Yoshihiro Takahashi, et al.
Được phát hành: (2009-01-01)

Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues.
Bằng: A H Merrill, Jr, et al.
Được phát hành: (1985-05-01)

Preparation of HeLa Total Membranes and Assay of Lipid-inhibition of Serine Palmitoyltransferase Activity
Bằng: Muthukumar Kannan, et al.
Được phát hành: (2020-06-01)

Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways
Bằng: Viktor Bugajev, et al.
Được phát hành: (2021-01-01)

Utilization of different fatty acyl-CoA thioesters by serine palmitoyltransferase from rat brain.
Bằng: A H Merrill, Jr, et al.
Được phát hành: (1984-02-01)

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis
Bằng: Andrew Kuo, et al.
Được phát hành: (2022-10-01)

The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins
Bằng: Carolin Körner, et al.
Được phát hành: (2024-08-01)

Enzymology of long-chain base synthesis by aorta: induction of serine palmitoyltransferase activity in rabbit aorta during atherogenesis.
Bằng: R D Williams, et al.
Được phát hành: (1988-09-01)

Serine Palmitoyltransferase Gene Silencing Prevents Ceramide Accumulation and Insulin Resistance in Muscles in Mice Fed a High-Fat Diet
Bằng: Monika Imierska, et al.
Được phát hành: (2022-03-01)

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S]
Bằng: Irina Gorshkova, et al.
Được phát hành: (2012-08-01)

Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes.
Bằng: Agnieszka Mikłosz, et al.
Được phát hành: (2013-01-01)

Insights Into the Known 13C Depletion of Methane—Contribution of the Kinetic Isotope Effects on the Serine Hydroxymethyltransferase Reaction
Bằng: Gerd Gleixner
Được phát hành: (2022-01-01)

Identification and Characterization of Carnitine Palmitoyltransferase 1 () Genes in Nile Tilapia,
Bằng: Mehtap Bayır, et al.
Được phát hành: (2020-03-01)

Neonatal Carnitine Palmitoyltransferase II Deficiency: A Lethal Entity
Bằng: Sushma Malik, et al.
Được phát hành: (2015-10-01)

A mini review of small-molecule inhibitors targeting palmitoyltransferases
Bằng: Xiaotong Hu, et al.
Được phát hành: (2022-08-01)

Carnitine palmitoyltransferase-II deficiency: case presentation and review of the literature
Bằng: Mccormick Benjamin J., et al.
Được phát hành: (2021-12-01)

Screening of Saccharomyces cerevisiae metabolite transporters by 13C isotope substrate labeling
Bằng: Lyubomir Dimitrov Stanchev, et al.
Được phát hành: (2023-11-01)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
Bằng: Kiran Kurmi, et al.
Được phát hành: (2018-02-01)

Analytical methods for stable isotope labeling to elucidate rapid auxin kinetics in Arabidopsis thaliana.
Bằng: Qian Tang, et al.
Được phát hành: (2024-01-01)

Hexokinase and carnitine palmitoyltransferase activities in flight muscles of grasshopper Valanga nigricornis(burm.)
Bằng: Lee, C. W., et al.
Được phát hành: (1983)

PP-050 Carnitine palmitoyltransferase I deficiency case reporting in Krasnodar region
Bằng: Natalia Shatokhina, et al.
Được phát hành: (2024-07-01)

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2
Bằng: Minxuan Xu, et al.
Được phát hành: (2023-12-01)

Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach
Bằng: Pushpa Raj Joshi, et al.
Được phát hành: (2020-04-01)

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2
Bằng: Minxuan Xu, et al.
Được phát hành: (2023-10-01)

Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy?
Bằng: Muyun Wang, et al.
Được phát hành: (2021-10-01)

Inhibition of carnitine palmitoyltransferase in the rat small intestine reduces export of triacylglycerol into the lymph
Bằng: LaTonya Washington, et al.
Được phát hành: (2003-07-01)

Direct Infusion Mass Spectrometry to Rapidly Map Metabolic Flux of Substrates Labeled with Stable Isotopes
Bằng: Nils W. F. Meijer, et al.
Được phát hành: (2024-04-01)

Investigation on substrate specificity and catalytic activity of serine protease neuropsin
Bằng: Masami Lintuluoto, et al.
Được phát hành: (2022-10-01)

Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods.
Bằng: K Ikewaki, et al.
Được phát hành: (1993-12-01)

Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes.
Bằng: KG Parhofer, et al.
Được phát hành: (1991-08-01)

Clinical and literature review of a case of myopathic form of carnitine palmitoyltransferase Ⅱ deficiency
Bằng: LU Guangshuang, XIA Mingnong, CHENG Yun, HU Jie, LI Wenbo, ZHANG Fan, YANG Wu
Được phát hành: (2024-10-01)

Carnitne Palmitoyltransferase II Defciency, a Rare Cause of Rhabdomyolysis: A Case Report
Bằng: Parisa Farshchi, et al.
Được phát hành: (2019-11-01)