Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalysed reactions. Isotopically-labelled L-serine is often used to monitor the activity of the first enzyme in sphingolipid biosynthesis, serine palmitoyltrans...

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Dades bibliogràfiques
Autors principals:	Harrison, PJ, Gable, K, Somashekarappa, N, Kelly, V, Clarke, DJ, Naismith, JH, Dunn, TM, Campopiano, DJ
Format:	Journal article
Idioma:	English
Publicat:	American Society for Biochemistry and Molecular Biology 2019

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