Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalysed reactions. Isotopically-labelled L-serine is often used to monitor the activity of the first enzyme in sphingolipid biosynthesis, serine palmitoyltrans...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Harrison, PJ, Gable, K, Somashekarappa, N, Kelly, V, Clarke, DJ, Naismith, JH, Dunn, TM, Campopiano, DJ
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	American Society for Biochemistry and Molecular Biology 2019

Eitemau Tebyg

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase
gan: Peter J. Harrison, et al.
Cyhoeddwyd: (2019-05-01)

Erratum: Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase
gan: Peter J. Harrison, et al.
Cyhoeddwyd: (2019-08-01)

An improved method to determine serine palmitoyltransferase activity
gan: Markus F. Ru¨tti, et al.
Cyhoeddwyd: (2009-06-01)

Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
gan: Yuancai Xiang, et al.
Cyhoeddwyd: (2021-03-01)

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis
gan: Deanna Siow, et al.
Cyhoeddwyd: (2015-04-01)

Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine.
gan: R D Williams, et al.
Cyhoeddwyd: (1987-12-01)

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition
gan: Sandra Hoefgen, et al.
Cyhoeddwyd: (2022-10-01)

Specialized acyl carrier protein used by serine palmitoyltransferase to synthesize sphingolipids in Rhodobacteria
gan: Jonathan Padilla-Gómez, et al.
Cyhoeddwyd: (2022-08-01)

Serine Palmitoyltransferase, the First Step Enzyme in Sphingolipid Biosynthesis, Is Involved in Nonhost Resistance
gan: Yoshihiro Takahashi, et al.
Cyhoeddwyd: (2009-01-01)

Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues.
gan: A H Merrill, Jr, et al.
Cyhoeddwyd: (1985-05-01)

Preparation of HeLa Total Membranes and Assay of Lipid-inhibition of Serine Palmitoyltransferase Activity
gan: Muthukumar Kannan, et al.
Cyhoeddwyd: (2020-06-01)

Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways
gan: Viktor Bugajev, et al.
Cyhoeddwyd: (2021-01-01)

Utilization of different fatty acyl-CoA thioesters by serine palmitoyltransferase from rat brain.
gan: A H Merrill, Jr, et al.
Cyhoeddwyd: (1984-02-01)

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis
gan: Andrew Kuo, et al.
Cyhoeddwyd: (2022-10-01)

The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins
gan: Carolin Körner, et al.
Cyhoeddwyd: (2024-08-01)

Enzymology of long-chain base synthesis by aorta: induction of serine palmitoyltransferase activity in rabbit aorta during atherogenesis.
gan: R D Williams, et al.
Cyhoeddwyd: (1988-09-01)

Serine Palmitoyltransferase Gene Silencing Prevents Ceramide Accumulation and Insulin Resistance in Muscles in Mice Fed a High-Fat Diet
gan: Monika Imierska, et al.
Cyhoeddwyd: (2022-03-01)

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S]
gan: Irina Gorshkova, et al.
Cyhoeddwyd: (2012-08-01)

Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes.
gan: Agnieszka Mikłosz, et al.
Cyhoeddwyd: (2013-01-01)

Insights Into the Known 13C Depletion of Methane—Contribution of the Kinetic Isotope Effects on the Serine Hydroxymethyltransferase Reaction
gan: Gerd Gleixner
Cyhoeddwyd: (2022-01-01)

Identification and Characterization of Carnitine Palmitoyltransferase 1 () Genes in Nile Tilapia,
gan: Mehtap Bayır, et al.
Cyhoeddwyd: (2020-03-01)

Neonatal Carnitine Palmitoyltransferase II Deficiency: A Lethal Entity
gan: Sushma Malik, et al.
Cyhoeddwyd: (2015-10-01)

A mini review of small-molecule inhibitors targeting palmitoyltransferases
gan: Xiaotong Hu, et al.
Cyhoeddwyd: (2022-08-01)

Carnitine palmitoyltransferase-II deficiency: case presentation and review of the literature
gan: Mccormick Benjamin J., et al.
Cyhoeddwyd: (2021-12-01)

Screening of Saccharomyces cerevisiae metabolite transporters by 13C isotope substrate labeling
gan: Lyubomir Dimitrov Stanchev, et al.
Cyhoeddwyd: (2023-11-01)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
gan: Kiran Kurmi, et al.
Cyhoeddwyd: (2018-02-01)

Analytical methods for stable isotope labeling to elucidate rapid auxin kinetics in Arabidopsis thaliana.
gan: Qian Tang, et al.
Cyhoeddwyd: (2024-01-01)

Hexokinase and carnitine palmitoyltransferase activities in flight muscles of grasshopper Valanga nigricornis(burm.)
gan: Lee, C. W., et al.
Cyhoeddwyd: (1983)

PP-050 Carnitine palmitoyltransferase I deficiency case reporting in Krasnodar region
gan: Natalia Shatokhina, et al.
Cyhoeddwyd: (2024-07-01)

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2
gan: Minxuan Xu, et al.
Cyhoeddwyd: (2023-12-01)

Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach
gan: Pushpa Raj Joshi, et al.
Cyhoeddwyd: (2020-04-01)

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2
gan: Minxuan Xu, et al.
Cyhoeddwyd: (2023-10-01)

Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy?
gan: Muyun Wang, et al.
Cyhoeddwyd: (2021-10-01)

Inhibition of carnitine palmitoyltransferase in the rat small intestine reduces export of triacylglycerol into the lymph
gan: LaTonya Washington, et al.
Cyhoeddwyd: (2003-07-01)

Direct Infusion Mass Spectrometry to Rapidly Map Metabolic Flux of Substrates Labeled with Stable Isotopes
gan: Nils W. F. Meijer, et al.
Cyhoeddwyd: (2024-04-01)

Investigation on substrate specificity and catalytic activity of serine protease neuropsin
gan: Masami Lintuluoto, et al.
Cyhoeddwyd: (2022-10-01)

Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods.
gan: K Ikewaki, et al.
Cyhoeddwyd: (1993-12-01)

Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes.
gan: KG Parhofer, et al.
Cyhoeddwyd: (1991-08-01)

Clinical and literature review of a case of myopathic form of carnitine palmitoyltransferase Ⅱ deficiency
gan: LU Guangshuang, XIA Mingnong, CHENG Yun, HU Jie, LI Wenbo, ZHANG Fan, YANG Wu
Cyhoeddwyd: (2024-10-01)

Carnitne Palmitoyltransferase II Defciency, a Rare Cause of Rhabdomyolysis: A Case Report
gan: Parisa Farshchi, et al.
Cyhoeddwyd: (2019-11-01)