A genome wide scan for early onset primary hypertension in Scandinavians.

With the aim of identifying hypertension susceptibility loci, we performed a genome wide scan in Scandinavian sib-pairs with early onset primary hypertension. To be classified as affected, a diagnosis of primary hypertension at age <!--=50 years was required. Two hundred and forty three patients...

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Bibliographic Details
Main Authors: von Wowern, F, Bengtsson, K, Lindgren, C, Orho-Melander, M, Fyhrquist, F, Lindblad, U, Råstam, L, Forsblom, C, Kanninen, T, Almgren, P, Burri, P, Katzman, P, Groop, L, Hulthén, U, Melander, O
Format: Journal article
Language:English
Published: 2003
Description
Summary:With the aim of identifying hypertension susceptibility loci, we performed a genome wide scan in Scandinavian sib-pairs with early onset primary hypertension. To be classified as affected, a diagnosis of primary hypertension at age <!--=50 years was required. Two hundred and forty three patients with onset of primary hypertension at 40.0+/-7.7 (mean+/-SD) years from 91 families (91 sib-ships with a mean of 2.7 and a range of 2-6 affected members per sib-ship) were genotyped with 362 microsatellite markers with a density of approximately 10 cM. Loci obtaining nominal P</=0.016 (LOD score -->/= 1.0) were fine mapped with additional markers. Multipoint non-parametric linkage analysis was performed using GENEHUNTER v 2.0. Using simulations, a nominal P