A genome wide scan for early onset primary hypertension in Scandinavians.
With the aim of identifying hypertension susceptibility loci, we performed a genome wide scan in Scandinavian sib-pairs with early onset primary hypertension. To be classified as affected, a diagnosis of primary hypertension at age <!--=50 years was required. Two hundred and forty three patients...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1826270696662106112 |
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| author | von Wowern, F Bengtsson, K Lindgren, C Orho-Melander, M Fyhrquist, F Lindblad, U Råstam, L Forsblom, C Kanninen, T Almgren, P Burri, P Katzman, P Groop, L Hulthén, U Melander, O |
| author_facet | von Wowern, F Bengtsson, K Lindgren, C Orho-Melander, M Fyhrquist, F Lindblad, U Råstam, L Forsblom, C Kanninen, T Almgren, P Burri, P Katzman, P Groop, L Hulthén, U Melander, O |
| author_sort | von Wowern, F |
| collection | OXFORD |
| description | With the aim of identifying hypertension susceptibility loci, we performed a genome wide scan in Scandinavian sib-pairs with early onset primary hypertension. To be classified as affected, a diagnosis of primary hypertension at age <!--=50 years was required. Two hundred and forty three patients with onset of primary hypertension at 40.0+/-7.7 (mean+/-SD) years from 91 families (91 sib-ships with a mean of 2.7 and a range of 2-6 affected members per sib-ship) were genotyped with 362 microsatellite markers with a density of approximately 10 cM. Loci obtaining nominal P</=0.016 (LOD score -->/= 1.0) were fine mapped with additional markers. Multipoint non-parametric linkage analysis was performed using GENEHUNTER v 2.0. Using simulations, a nominal P |
| first_indexed | 2024-03-06T21:44:53Z |
| format | Journal article |
| id | oxford-uuid:4939d51a-e3b3-4577-9272-e3d134b39207 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:44:53Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:4939d51a-e3b3-4577-9272-e3d134b392072022-03-26T15:30:25ZA genome wide scan for early onset primary hypertension in Scandinavians.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4939d51a-e3b3-4577-9272-e3d134b39207EnglishSymplectic Elements at Oxford2003von Wowern, FBengtsson, KLindgren, COrho-Melander, MFyhrquist, FLindblad, URåstam, LForsblom, CKanninen, TAlmgren, PBurri, PKatzman, PGroop, LHulthén, UMelander, OWith the aim of identifying hypertension susceptibility loci, we performed a genome wide scan in Scandinavian sib-pairs with early onset primary hypertension. To be classified as affected, a diagnosis of primary hypertension at age <!--=50 years was required. Two hundred and forty three patients with onset of primary hypertension at 40.0+/-7.7 (mean+/-SD) years from 91 families (91 sib-ships with a mean of 2.7 and a range of 2-6 affected members per sib-ship) were genotyped with 362 microsatellite markers with a density of approximately 10 cM. Loci obtaining nominal P</=0.016 (LOD score -->/= 1.0) were fine mapped with additional markers. Multipoint non-parametric linkage analysis was performed using GENEHUNTER v 2.0. Using simulations, a nominal P |
| spellingShingle | von Wowern, F Bengtsson, K Lindgren, C Orho-Melander, M Fyhrquist, F Lindblad, U Råstam, L Forsblom, C Kanninen, T Almgren, P Burri, P Katzman, P Groop, L Hulthén, U Melander, O A genome wide scan for early onset primary hypertension in Scandinavians. |
| title | A genome wide scan for early onset primary hypertension in Scandinavians. |
| title_full | A genome wide scan for early onset primary hypertension in Scandinavians. |
| title_fullStr | A genome wide scan for early onset primary hypertension in Scandinavians. |
| title_full_unstemmed | A genome wide scan for early onset primary hypertension in Scandinavians. |
| title_short | A genome wide scan for early onset primary hypertension in Scandinavians. |
| title_sort | genome wide scan for early onset primary hypertension in scandinavians |
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