The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability.

The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability.

Bidirectionally moving DNA replication forks merge at termination sites composed of accidental or programmed DNA-protein barriers. If merging fails, then regions of unreplicated DNA can result in the breakage of DNA during mitosis, which in turn can give rise to genome instability. Despite its impor...

Bibliografski detalji
Glavni autori:	Steinacher, R, Osman, F, Dalgaard, J, Lorenz, A, Whitby, M
Format:	Journal article
Jezik:	English
Izdano:	2012

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