Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

<p><strong>Background</strong></p> We previously developed an African-ancestry-specific polygenic hazard score (PHS46+African) that substantially improved prostate cancer risk stratification in men with African ancestry. The model consists of 46 SNPs identified in Europeans a...

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Hlavní autoři: Karunamuni, RA, Huynh-Le, M-P, Fan, CC, Thompson, W, Lui, A, Martinez, ME, Rose, BS, Mahal, B, Eeles, RA, Kote-Jarai, Z, Muir, K, Lophatananon, A, Tangen, CM, Goodman, PJ, Thompson, IM, Blot, WJ, Zheng, W, Kibel, AS, Drake, BF, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Park, JY, Lin, H-Y, Taylor, JA, Bensen, JT, Mohler, JL, Fontham, ETH, Multigner, L, Blanchet, P, Brureau, L, Romana, M, Leach, RJ, John, EM, Fowke, JH, Bush, WS, Aldrich, MC, Crawford, DC, Cullen, J, Petrovics, G, Parent, M-É, Hu, JJ, Sanderson, M, Mills, IG, Andreassen, OA, Dale, AM, Seibert, TM
Další autoři: UKGPCS Collaborators
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature 2021

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