Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres.
Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulated with hydrophilic drugs have been successfully prepared by a solid-in-oil-in-water (s/o/w) solvent evaporation method in the presence of anionic surfactants, sodium dodecyl sulfate (SDS), and dioctyl sodium sulfosuccina...
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1797066703440445440 |
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| author | Xu, Q Crossley, A Czernuszka, J |
| author_facet | Xu, Q Crossley, A Czernuszka, J |
| author_sort | Xu, Q |
| collection | OXFORD |
| description | Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulated with hydrophilic drugs have been successfully prepared by a solid-in-oil-in-water (s/o/w) solvent evaporation method in the presence of anionic surfactants, sodium dodecyl sulfate (SDS), and dioctyl sodium sulfosuccinate (DSS), and nonionic surfactant polyvinyl alcohol (PVA). The effects of microencapsulation methods, surfactants types, and surfactant concentrations on the properties of microspheres were studied. Amoxicillin (AMX) was chosen as a hydrophilic model drug, and its encapsulation efficiency (EE) and in vitro release profiles were measured. The s/o/w method achieved higher EE of 40% in PLGA microspheres using surfactant SDS compared with the conventional water-in-oil-in-water (w/o/w) method (about 2%). Triphasic release profiles were observed for all PLGA microspheres (s/o/w) with slight drug burst, a slow diffusion-controlled release within the period of about 7 days and followed by the degradation-controlled sustained release for further 30 days. Smaller particle size and surface charge were achieved for s/o/w method than w/o/w method using the same anionic surfactants, and smooth surface and less porous interior matrix. The s/o/w method effectively encapsulated AMX into anionic PLGA microspheres using anionic surfactants, and these negatively charged PLGA microspheres represented an attractive approach for the controlled release of hydrophilic drugs. |
| first_indexed | 2024-03-06T21:45:49Z |
| format | Journal article |
| id | oxford-uuid:498b980a-4da9-4e97-92a6-8f3fdcc524b9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:45:49Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:498b980a-4da9-4e97-92a6-8f3fdcc524b92022-03-26T15:32:24ZPreparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:498b980a-4da9-4e97-92a6-8f3fdcc524b9EnglishSymplectic Elements at Oxford2009Xu, QCrossley, ACzernuszka, JNegatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulated with hydrophilic drugs have been successfully prepared by a solid-in-oil-in-water (s/o/w) solvent evaporation method in the presence of anionic surfactants, sodium dodecyl sulfate (SDS), and dioctyl sodium sulfosuccinate (DSS), and nonionic surfactant polyvinyl alcohol (PVA). The effects of microencapsulation methods, surfactants types, and surfactant concentrations on the properties of microspheres were studied. Amoxicillin (AMX) was chosen as a hydrophilic model drug, and its encapsulation efficiency (EE) and in vitro release profiles were measured. The s/o/w method achieved higher EE of 40% in PLGA microspheres using surfactant SDS compared with the conventional water-in-oil-in-water (w/o/w) method (about 2%). Triphasic release profiles were observed for all PLGA microspheres (s/o/w) with slight drug burst, a slow diffusion-controlled release within the period of about 7 days and followed by the degradation-controlled sustained release for further 30 days. Smaller particle size and surface charge were achieved for s/o/w method than w/o/w method using the same anionic surfactants, and smooth surface and less porous interior matrix. The s/o/w method effectively encapsulated AMX into anionic PLGA microspheres using anionic surfactants, and these negatively charged PLGA microspheres represented an attractive approach for the controlled release of hydrophilic drugs. |
| spellingShingle | Xu, Q Crossley, A Czernuszka, J Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres. |
| title | Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres. |
| title_full | Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres. |
| title_fullStr | Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres. |
| title_full_unstemmed | Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres. |
| title_short | Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres. |
| title_sort | preparation and characterization of negatively charged poly lactic co glycolic acid microspheres |
| work_keys_str_mv | AT xuq preparationandcharacterizationofnegativelychargedpolylacticcoglycolicacidmicrospheres AT crossleya preparationandcharacterizationofnegativelychargedpolylacticcoglycolicacidmicrospheres AT czernuszkaj preparationandcharacterizationofnegativelychargedpolylacticcoglycolicacidmicrospheres |