A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)¹⁻⁷, a modest number considering the apparent heritability of CAD⁸. All of these variants have been discovered in European populations. We report a meta-analysis of four large...
| Main Author: | |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1826270765225345024 |
|---|---|
| author | Coronary Artery Disease (C4D) Genetics Consortium |
| author_facet | Coronary Artery Disease (C4D) Genetics Consortium |
| author_sort | Coronary Artery Disease (C4D) Genetics Consortium |
| collection | OXFORD |
| description | Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)¹⁻⁷, a modest number considering the apparent heritability of CAD⁸. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ∼575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10⁻⁸ in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility. |
| first_indexed | 2024-03-06T21:45:58Z |
| format | Journal article |
| id | oxford-uuid:499c3c38-8e12-4fd5-a783-2ad50c76c75f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:45:58Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:499c3c38-8e12-4fd5-a783-2ad50c76c75f2022-03-26T15:32:31ZA genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:499c3c38-8e12-4fd5-a783-2ad50c76c75fEnglishSymplectic Elements at Oxford2011Coronary Artery Disease (C4D) Genetics ConsortiumGenome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)¹⁻⁷, a modest number considering the apparent heritability of CAD⁸. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ∼575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10⁻⁸ in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility. |
| spellingShingle | Coronary Artery Disease (C4D) Genetics Consortium A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. |
| title | A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. |
| title_full | A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. |
| title_fullStr | A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. |
| title_full_unstemmed | A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. |
| title_short | A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. |
| title_sort | genome wide association study in europeans and south asians identifies five new loci for coronary artery disease |
| work_keys_str_mv | AT coronaryarterydiseasec4dgeneticsconsortium agenomewideassociationstudyineuropeansandsouthasiansidentifiesfivenewlociforcoronaryarterydisease AT coronaryarterydiseasec4dgeneticsconsortium genomewideassociationstudyineuropeansandsouthasiansidentifiesfivenewlociforcoronaryarterydisease |