Modelling of the microglial response to neuronal α-synuclein aggregation

Modelling of the microglial response to neuronal α-synuclein aggregation

Parkinson’s disease is the second most common neurodegenerative disease, characterised by α-synuclein aggregation and loss of dopaminergic and other types of neurons. Inflammation, the activation of microglial and other immune cells in response to pathology, is a well-documented feature of the neur...

Mô tả đầy đủ

Chi tiết về thư mục
Tác giả chính:	Katsikoudi, A
Tác giả khác:	Tofaris, G
Định dạng:	Luận văn
Ngôn ngữ:	English
Được phát hành:	2022
Những chủ đề:	Neuroscience

Những quyển sách tương tự

Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase
Bằng: Ting Yu, et al.
Được phát hành: (2023-11-01)

Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson’s disease
Bằng: Maxime Teixeira, et al.
Được phát hành: (2023-12-01)

Protocol for generation of PD-modeling-induced neurons and detection of α-synuclein forms
Bằng: Francesco V. Nardi, et al.
Được phát hành: (2024-12-01)

Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson’s disease
Bằng: Anthony L. Gaeta, et al.
Được phát hành: (2023-06-01)

Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity
Bằng: Na Wang, et al.
Được phát hành: (2024-06-01)

20S proteasome enhancers prevent cytotoxic tubulin polymerization-promoting protein induced α-synuclein aggregation
Bằng: Sophia D. Staerz, et al.
Được phát hành: (2024-07-01)

Metabolic rescue of α-synuclein-induced neurodegeneration through propionate supplementation and intestine-neuron signaling in C. elegans
Bằng: Chenyin Wang, et al.
Được phát hành: (2024-03-01)

SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation
Bằng: Katsutoshi Taguchi, et al.
Được phát hành: (2025-02-01)

Investigating microglia-neuron crosstalk by characterizing microglial contamination in human and mouse patch-seq datasets
Bằng: Keon Arbabi, et al.
Được phát hành: (2023-08-01)

Protocol for the intracerebral injection of AAV-α-synuclein plus poly(ADP-ribose) to generate a Parkinson’s disease monkey model
Bằng: Shuyi Liu, et al.
Được phát hành: (2025-03-01)

Mutant α-synuclein propagates via the lymphatic system of the brain in the monomeric state
Bằng: Kyota Fujita, et al.
Được phát hành: (2023-08-01)

Chronic carbon disulfide exposure induces parkinsonian pathology via α-synuclein aggregation and necrosome complex interaction
Bằng: Zhidan Liu, et al.
Được phát hành: (2023-10-01)

Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology
Bằng: Manasee Gedam, et al.
Được phát hành: (2023-06-01)

FcγRIIB mediates the inhibitory effect of aggregated α-synuclein on microglial phagocytosis
Bằng: Yu Ree Choi, et al.
Được phát hành: (2015-11-01)

Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s disease
Bằng: Guoqiang George Sun, et al.
Được phát hành: (2024-12-01)

Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation
Bằng: Nanxia Zhao, et al.
Được phát hành: (2020-02-01)

α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
Bằng: Jonathan D. Horvath, et al.
Được phát hành: (2023-10-01)

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
Bằng: Sangderk Lee, et al.
Được phát hành: (2023-03-01)

Investigating brain-derived α-synuclein fibrils and diagnostic biomarkers of synucleinopathies
Bằng: Lee, S
Được phát hành: (2023)

Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo
Bằng: Seok Joon Won, et al.
Được phát hành: (2022-12-01)

Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation
Bằng: Liqiang Chen, et al.
Được phát hành: (2025-01-01)

Modulation of microglial metabolism facilitates regeneration in demyelination
Bằng: Chuan Qin, et al.
Được phát hành: (2023-05-01)

NGLY1 mutations cause protein aggregation in human neurons
Bằng: Andreea Manole, et al.
Được phát hành: (2023-12-01)

The role of alpha-synuclein oligomers in Parkinson's disease pathophysiology and biology
Bằng: Roberts, R
Được phát hành: (2015)

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Bằng: Alvarez-Erviti, L, et al.
Được phát hành: (2011)

Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo
Bằng: Jie Xiang, et al.
Được phát hành: (2024-03-01)

A comparative analysis of microglial inducible Cre lines
Bằng: Travis E. Faust, et al.
Được phát hành: (2023-09-01)

Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates
Bằng: Leonardo Acuña, et al.
Được phát hành: (2019-07-01)

Microglial P2X4 receptors are essential for spinal neurons hyperexcitability and tactile allodynia in male and female neuropathic mice
Bằng: Damien Gilabert, et al.
Được phát hành: (2023-11-01)

Neuronal response of the primate striatum tail to face of socially familiar persons
Bằng: Jun Kunimatsu, et al.
Được phát hành: (2024-06-01)

Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria
Bằng: Ranabir Chakraborty, et al.
Được phát hành: (2023-05-01)

Monitoring α-synuclein aggregation
Bằng: Juan Estaun-Panzano, et al.
Được phát hành: (2023-01-01)

Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development
Bằng: James Hennegan, et al.
Được phát hành: (2024-01-01)

Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein
Bằng: Na Li, et al.
Được phát hành: (2020-09-01)

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.
Bằng: Alvarez-Erviti, L, et al.
Được phát hành: (2011)

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line
Bằng: Alvarez-Erviti, L, et al.
Được phát hành: (2011)

CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology
Bằng: Mads N. Olesen, et al.
Được phát hành: (2018-01-01)

A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models
Bằng: Alicia M. Bedolla, et al.
Được phát hành: (2024-01-01)

Temporal responses of bumblebee gustatory neurons to sugars
Bằng: Rachel H. Parkinson, et al.
Được phát hành: (2022-07-01)

Functional characterisation of synuclein-based novel genetic mouse models
Bằng: Anwar, S
Được phát hành: (2011)