Cotranslational protein folding - fact or fiction?
Motivation: Experimentalists have amassed extensive evidence over the past four decades that proteins appear to fold during production by the ribosome. Protein structure prediction methods, however, do not incorporate this property of folding. A thorough study to find the fingerprint of such sequent...
| Principais autores: | , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: |
| _version_ | 1826270785040285696 |
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| author | Deane, C Dong, M Huard, F Lance, B Wood, G |
| author_facet | Deane, C Dong, M Huard, F Lance, B Wood, G |
| author_sort | Deane, C |
| collection | OXFORD |
| description | Motivation: Experimentalists have amassed extensive evidence over the past four decades that proteins appear to fold during production by the ribosome. Protein structure prediction methods, however, do not incorporate this property of folding. A thorough study to find the fingerprint of such sequential folding is the first step towards using it in folding algorithms, so assisting structure prediction. Results: We explore computationally the existence of evidence for cotranslational folding, based on large sets of experimentally determined structures in the PDB. Our perspective is that cotranslational folding is the norm, but that the effect is masked in most classes. We show that it is most evident in α/β proteins, confirming recent findings. We also find mild evidence that older proteins may fold cotranslationally. A tool is provided for determining, within a protein, where cotranslation is most evident. |
| first_indexed | 2024-03-06T21:46:16Z |
| format | Journal article |
| id | oxford-uuid:49b58ec2-57af-4147-a409-d3f4bf29a688 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:46:16Z |
| publishDate | 2007 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:49b58ec2-57af-4147-a409-d3f4bf29a6882022-03-26T15:33:10ZCotranslational protein folding - fact or fiction?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:49b58ec2-57af-4147-a409-d3f4bf29a688Statistics (see also social sciences)Mathematical genetics and bioinformatics (statistics)EnglishOxford University Research Archive - ValetOxford University Press2007Deane, CDong, MHuard, FLance, BWood, GMotivation: Experimentalists have amassed extensive evidence over the past four decades that proteins appear to fold during production by the ribosome. Protein structure prediction methods, however, do not incorporate this property of folding. A thorough study to find the fingerprint of such sequential folding is the first step towards using it in folding algorithms, so assisting structure prediction. Results: We explore computationally the existence of evidence for cotranslational folding, based on large sets of experimentally determined structures in the PDB. Our perspective is that cotranslational folding is the norm, but that the effect is masked in most classes. We show that it is most evident in α/β proteins, confirming recent findings. We also find mild evidence that older proteins may fold cotranslationally. A tool is provided for determining, within a protein, where cotranslation is most evident. |
| spellingShingle | Statistics (see also social sciences) Mathematical genetics and bioinformatics (statistics) Deane, C Dong, M Huard, F Lance, B Wood, G Cotranslational protein folding - fact or fiction? |
| title | Cotranslational protein folding - fact or fiction? |
| title_full | Cotranslational protein folding - fact or fiction? |
| title_fullStr | Cotranslational protein folding - fact or fiction? |
| title_full_unstemmed | Cotranslational protein folding - fact or fiction? |
| title_short | Cotranslational protein folding - fact or fiction? |
| title_sort | cotranslational protein folding fact or fiction |
| topic | Statistics (see also social sciences) Mathematical genetics and bioinformatics (statistics) |
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