Preterm birth is a novel, independent risk factor for altered cardiac remodeling and early heart failure: is it time for a new cardiomyopathy?
<p><strong>Purpose of review</strong></p><p>Around 10% of the global population is born preterm (< 37 weeks’ gestation). Preterm birth is associated with an increased risk of cardiovascular events, with preterm-born individuals demonstrating a distinct cardiac ph...
| Egile Nagusiak: | , |
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| Formatua: | Journal article |
| Argitaratua: |
Springer
2019
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| _version_ | 1826270790523289600 |
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| author | Burchert, H Lewandowski, A |
| author_facet | Burchert, H Lewandowski, A |
| author_sort | Burchert, H |
| collection | OXFORD |
| description | <p><strong>Purpose of review</strong></p><p>Around 10% of the global population is born preterm (< 37 weeks’ gestation). Preterm birth is associated with an increased risk of cardiovascular events, with preterm-born individuals demonstrating a distinct cardiac phenotype. This review aims to summarize the main phenotypic features of the preterm heart and directions for future research to develop novel intervention strategies.</p><p><strong>Recent findings</strong></p> <p>Being born between 28 and 31 weeks’ gestation results in a 4-fold higher risk of heart failure in childhood and adolescence and 17-fold increased risk when born less than 28 weeks’ gestation. In support of this being due to a reduction in myocardial functional reserve, preterm-born young adults have an impaired left ventricular cardiac systolic response to moderate and high intensity physiological stress, despite having a preserved resting left ventricular ejection fraction. Similar impairments under physiological stress were also recently reported regarding the right ventricle in young adults born preterm.</p><p><strong>Summary</strong></p> <p>Preterm birth relates to a unique cardiac phenotype with an impaired response to stress conditions. These data, combined with the work in animal models, suggest that being born preterm may lead to a novel form of cardiomyopathy. Understanding the driving mechanisms leading to this unique cardiac phenotype is important to reduce risk of future heart failure and cardiovascular events.</p> |
| first_indexed | 2024-03-06T21:46:21Z |
| format | Journal article |
| id | oxford-uuid:49bb024b-d803-4071-91d8-ec8558cc9ca5 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:46:21Z |
| publishDate | 2019 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:49bb024b-d803-4071-91d8-ec8558cc9ca52022-03-26T15:33:19ZPreterm birth is a novel, independent risk factor for altered cardiac remodeling and early heart failure: is it time for a new cardiomyopathy?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:49bb024b-d803-4071-91d8-ec8558cc9ca5Symplectic Elements at OxfordSpringer2019Burchert, HLewandowski, A<p><strong>Purpose of review</strong></p><p>Around 10% of the global population is born preterm (< 37 weeks’ gestation). Preterm birth is associated with an increased risk of cardiovascular events, with preterm-born individuals demonstrating a distinct cardiac phenotype. This review aims to summarize the main phenotypic features of the preterm heart and directions for future research to develop novel intervention strategies.</p><p><strong>Recent findings</strong></p> <p>Being born between 28 and 31 weeks’ gestation results in a 4-fold higher risk of heart failure in childhood and adolescence and 17-fold increased risk when born less than 28 weeks’ gestation. In support of this being due to a reduction in myocardial functional reserve, preterm-born young adults have an impaired left ventricular cardiac systolic response to moderate and high intensity physiological stress, despite having a preserved resting left ventricular ejection fraction. Similar impairments under physiological stress were also recently reported regarding the right ventricle in young adults born preterm.</p><p><strong>Summary</strong></p> <p>Preterm birth relates to a unique cardiac phenotype with an impaired response to stress conditions. These data, combined with the work in animal models, suggest that being born preterm may lead to a novel form of cardiomyopathy. Understanding the driving mechanisms leading to this unique cardiac phenotype is important to reduce risk of future heart failure and cardiovascular events.</p> |
| spellingShingle | Burchert, H Lewandowski, A Preterm birth is a novel, independent risk factor for altered cardiac remodeling and early heart failure: is it time for a new cardiomyopathy? |
| title | Preterm birth is a novel, independent risk factor for altered cardiac remodeling and early heart failure: is it time for a new cardiomyopathy? |
| title_full | Preterm birth is a novel, independent risk factor for altered cardiac remodeling and early heart failure: is it time for a new cardiomyopathy? |
| title_fullStr | Preterm birth is a novel, independent risk factor for altered cardiac remodeling and early heart failure: is it time for a new cardiomyopathy? |
| title_full_unstemmed | Preterm birth is a novel, independent risk factor for altered cardiac remodeling and early heart failure: is it time for a new cardiomyopathy? |
| title_short | Preterm birth is a novel, independent risk factor for altered cardiac remodeling and early heart failure: is it time for a new cardiomyopathy? |
| title_sort | preterm birth is a novel independent risk factor for altered cardiac remodeling and early heart failure is it time for a new cardiomyopathy |
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