Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, increased ventricular stiffness and impaired diastolic filling. We investigated to what extent myocardial functional defects can be explained by alterations in the passive and active properties of human cardiac myofi...
Main Authors: | Hoskins, A, Jacques, A, Bardswell, S, McKenna, W, Tsang, V, dos Remedios, C, Ehler, E, Adams, K, Jalilzadeh, S, Avkiran, M, Watkins, H, Redwood, C, Marston, S, Kentish, J |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2010
|
Similar Items
-
Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
by: Bayliss, C, et al.
Published: (2013) -
Evidence from human myectomy samples that MYBPC3 mutations cause hypertrophic cardiomyopathy through haploinsufficiency.
by: Marston, S, et al.
Published: (2009) -
Direct evidence in man for haploinsufficiency as the mechanism of action of myosin-binding protein C mutations that cause hypertrophic cardiomyopathy
by: Carballo, S, et al.
Published: (2008) -
The genetics of hypertrophic cardiomyopathy: Teare redux.
by: Watkins, H, et al.
Published: (2008) -
The prognostic impact of septal myectomy in obstructive hypertrophic cardiomyopathy.
by: Watkins, H, et al.
Published: (2005)