Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

A variety of analyses, including fluorescence in situ hybridization (FISH), quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series of chordomas from 181 patients. Twelve of 181 (7%) tumours displayed amplification of the T locus and an additional two cases showed focal amplifi...

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Bibliographic Details
Main Authors: Presneau, N, Shalaby, A, Ye, H, Pillay, N, Halai, D, Idowu, B, Tirabosco, R, Whitwell, D, Jacques, T, Kindblom, L, Brüderlein, S, Möller, P, Leithner, A, Liegl, B, Amary, F, Athanasou, N, Hogendoorn, P, Mertens, F, Szuhai, K, Flanagan, A
Format: Journal article
Language:English
Published: 2011

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