New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

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Protein kinase casein kinase 2 (CK2) is a serine/threonine kinase with evidence of implication in growth dysregulation and apoptosis resistance, making it a relevant target for cancer therapy. Several CK2 inhibitors have been developed showing variable efficiency, emphasizing the need to expand the...

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Podrobná bibliografie
Hlavní autoři: López-Ramos, M, Prudent, R, Moucadel, V, Sautel, C, Barette, C, Lafanechère, L, Mouawad, L, Grierson, D, Schmidt, F, Florent, J, Filippakopoulos, P, Bullock, A, Knapp, S, Reiser, J, Cochet, C
Médium: Journal article
Jazyk:English
Vydáno: 2010
Témata:
chemistry
Proto-Oncogene Proteins c-pim-1
Casein Kinase II
Humans
Crystallography, X-Ray
Binding Sites
Enzyme Inhibitors
Animals
Enzyme Activation
pharmacology
antagonists and inhibitors
drug effects
chemical synthesis
Cell Line, Tumor
Enzyme Stability

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