A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

The Bloom's syndrome protein, BLM, is a member of the conserved RecQ helicase family. Although cell lines lacking BLM exist, these exhibit progressive genomic instability that makes distinguishing primary from secondary effects of BLM loss problematic. In order to be able to acutely disable BLM...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Nguyen, G, Dexheimer, T, Rosenthal, A, Chu, W, Singh, D, Mosedale, G, Bachrati, C, Schultz, L, Sakurai, M, Savitsky, P, Abu, M, McHugh, P, Bohr, V, Harris, C, Jadhav, A, Gileadi, O, Maloney, D, Simeonov, A, Hickson, I
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: Cell Press 2013

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