A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

The Bloom's syndrome protein, BLM, is a member of the conserved RecQ helicase family. Although cell lines lacking BLM exist, these exhibit progressive genomic instability that makes distinguishing primary from secondary effects of BLM loss problematic. In order to be able to acutely disable BLM...

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Príomhchruthaitheoirí: Nguyen, G, Dexheimer, T, Rosenthal, A, Chu, W, Singh, D, Mosedale, G, Bachrati, C, Schultz, L, Sakurai, M, Savitsky, P, Abu, M, McHugh, P, Bohr, V, Harris, C, Jadhav, A, Gileadi, O, Maloney, D, Simeonov, A, Hickson, I
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Cell Press 2013

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