Enzymatic synthesis and photoswitchable enzymatic cleavage of a peptide-linked rotaxane.
(Figure Presented) Selective digestion: α-Chymotrypsin was used to synthesize a cyclodextrin azo dye rotaxane and to digest it back to its components. E → Z photoisomerization of the rotaxane completely changes its affinity for the enzyme. The presence of the cyclodextrin accelerates digestion of th...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| Summary: | (Figure Presented) Selective digestion: α-Chymotrypsin was used to synthesize a cyclodextrin azo dye rotaxane and to digest it back to its components. E → Z photoisomerization of the rotaxane completely changes its affinity for the enzyme. The presence of the cyclodextrin accelerates digestion of the E isomer and prevents that of the Z isomer. © 2006 Wiley-VCH Verlag GmbH and Co. KGaA. |
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