Atypical inflammatory demyelinating syndromes of the CNS

Atypical inflammatory demyelinating syndromes are rare disorders that differ from multiple sclerosis owing to unusual clinical or MRI findings or poor response to treatments used for multiple sclerosis. These syndromes include neuromyelitis optica spectrum disorder, acute disseminated encephalomyeli...

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Main Authors: Hardy, T, Reddel, S, Barnett, M, Palace, J, Lucchinetti, C, Weinshenker, B
Format: Journal article
Language:English
Published: Elsevier 2016
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author Hardy, T
Reddel, S
Barnett, M
Palace, J
Lucchinetti, C
Weinshenker, B
author_facet Hardy, T
Reddel, S
Barnett, M
Palace, J
Lucchinetti, C
Weinshenker, B
author_sort Hardy, T
collection OXFORD
description Atypical inflammatory demyelinating syndromes are rare disorders that differ from multiple sclerosis owing to unusual clinical or MRI findings or poor response to treatments used for multiple sclerosis. These syndromes include neuromyelitis optica spectrum disorder, acute disseminated encephalomyelitis, tumefactive demyelination, Baló's concentric sclerosis, Schilder's disease, and Marburg's multiple sclerosis. The overlapping features of these syndromes with multiple sclerosis and with each other complicate diagnosis and their categorisation as distinct or related conditions. Recognition of these syndromes is crucial because they differ from multiple sclerosis and other demyelinating and non-demyelinating conditions in their prognosis and treatment. Advances in MRI, pathology, and immunobiology are needed to increase understanding of these syndromes, including the extent to which some of them represent distinct entities, and to assist with improvements in their diagnosis and management.
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spelling oxford-uuid:49dc3a62-76a4-4b96-9900-a7cd41d5a61a2022-03-26T15:34:21ZAtypical inflammatory demyelinating syndromes of the CNSJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:49dc3a62-76a4-4b96-9900-a7cd41d5a61aEnglishSymplectic Elements at OxfordElsevier2016Hardy, TReddel, SBarnett, MPalace, JLucchinetti, CWeinshenker, BAtypical inflammatory demyelinating syndromes are rare disorders that differ from multiple sclerosis owing to unusual clinical or MRI findings or poor response to treatments used for multiple sclerosis. These syndromes include neuromyelitis optica spectrum disorder, acute disseminated encephalomyelitis, tumefactive demyelination, Baló's concentric sclerosis, Schilder's disease, and Marburg's multiple sclerosis. The overlapping features of these syndromes with multiple sclerosis and with each other complicate diagnosis and their categorisation as distinct or related conditions. Recognition of these syndromes is crucial because they differ from multiple sclerosis and other demyelinating and non-demyelinating conditions in their prognosis and treatment. Advances in MRI, pathology, and immunobiology are needed to increase understanding of these syndromes, including the extent to which some of them represent distinct entities, and to assist with improvements in their diagnosis and management.
spellingShingle Hardy, T
Reddel, S
Barnett, M
Palace, J
Lucchinetti, C
Weinshenker, B
Atypical inflammatory demyelinating syndromes of the CNS
title Atypical inflammatory demyelinating syndromes of the CNS
title_full Atypical inflammatory demyelinating syndromes of the CNS
title_fullStr Atypical inflammatory demyelinating syndromes of the CNS
title_full_unstemmed Atypical inflammatory demyelinating syndromes of the CNS
title_short Atypical inflammatory demyelinating syndromes of the CNS
title_sort atypical inflammatory demyelinating syndromes of the cns
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