MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

Cyclin B–dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it inhibits mitotic exit by activating the spindle checkpoint. This latter role is mediated through phosphorylation of the checkpoint kinase MPS1 and other spindle checkpoint proteins. We find that CDK1-CCNB1 localizes...

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Príomhchruthaitheoirí:	Alfonso-Pérez, T, Hayward, D, Holder, J, Gruneberg, U, Barr, F
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Rockefeller University Press 2019

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