ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth.
ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups died before weaning. This postnatal lethality was significantly enhanced in p53+/- background and both deletions are synthetic lethal. ASPP2+/- mice developed spontaneous tumors. The tumor onset was ac...
| Main Authors: | , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
2006
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| _version_ | 1826270844775563264 |
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| author | Vives, V Su, J Zhong, S Ratnayaka, I Slee, E Goldin, R Lu, X |
| author_facet | Vives, V Su, J Zhong, S Ratnayaka, I Slee, E Goldin, R Lu, X |
| author_sort | Vives, V |
| collection | OXFORD |
| description | ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups died before weaning. This postnatal lethality was significantly enhanced in p53+/- background and both deletions are synthetic lethal. ASPP2+/- mice developed spontaneous tumors. The tumor onset was accelerated by gamma-irradiation or in p53+/- background. Tumors derived from ASPP2+/- mice retained wild-type ASPP2 allele even though some of them lost p53. These provide the first genetic evidence that ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression. |
| first_indexed | 2024-03-06T21:47:13Z |
| format | Journal article |
| id | oxford-uuid:4a0364eb-a269-4bda-9cd5-55a4563967eb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:47:13Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:4a0364eb-a269-4bda-9cd5-55a4563967eb2022-03-26T15:35:06ZASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4a0364eb-a269-4bda-9cd5-55a4563967ebEnglishSymplectic Elements at Oxford2006Vives, VSu, JZhong, SRatnayaka, ISlee, EGoldin, RLu, XASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups died before weaning. This postnatal lethality was significantly enhanced in p53+/- background and both deletions are synthetic lethal. ASPP2+/- mice developed spontaneous tumors. The tumor onset was accelerated by gamma-irradiation or in p53+/- background. Tumors derived from ASPP2+/- mice retained wild-type ASPP2 allele even though some of them lost p53. These provide the first genetic evidence that ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression. |
| spellingShingle | Vives, V Su, J Zhong, S Ratnayaka, I Slee, E Goldin, R Lu, X ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. |
| title | ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. |
| title_full | ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. |
| title_fullStr | ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. |
| title_full_unstemmed | ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. |
| title_short | ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. |
| title_sort | aspp2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth |
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