The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.

The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.

Follicular helper T cells (TFH cells) are the prototypic helper T cell subset specialized to enable B cells to form germinal centers (GCs) and produce high-affinity antibodies. We found that expression of microRNAs (miRNAs) by T cells was essential for TFH cell differentiation. More specifically, we...

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Bibliographic Details
Main Authors: Baumjohann, D, Kageyama, R, Clingan, J, Morar, M, Patel, S, de Kouchkovsky, D, Bannard, O, Bluestone, J, Matloubian, M, Ansel, K, Jeker, LT
Format: Journal article
Language:English
Published: 2013

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