Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.

A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate oxygen delivery. We therefore studied the role of endothelial PHD2 in vessel shaping by implanting tumors in PHD2(+/-)...

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Bibliographic Details
Main Authors:	Mazzone, M, Dettori, D, Leite de Oliveira, R, Loges, S, Schmidt, T, Jonckx, B, Tian, Y, Lanahan, A, Pollard, P, Ruiz de Almodovar, C, De Smet, F, Vinckier, S, Aragonés, J, Debackere, K, Luttun, A, Wyns, S, Jordan, B, Pisacane, A, Gallez, B, Lampugnani, MG, Dejana, E, Simons, M, Ratcliffe, P, Maxwell, P, Carmeliet, P
Format:	Journal article
Language:	English
Published:	2009

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.

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