Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.

Lactate dehydrogenase-5 (LDH-5) catalyses the reversible transformation of pyruvate to lactate, having a principal position in the anaerobic cellular metabolism. Induction of LDH-5 occurs during hypoxia and LDH-5 transcription is directly regulated by the hypoxia-inducible factor 1 (HIF1). Serum LDH...

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Váldodahkkit: Koukourakis, M, Giatromanolaki, A, Sivridis, E, Bougioukas, G, Didilis, V, Gatter, K, Harris, A
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 2003