Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.

Recent data suggest that common variation in the transcription factor 7-like 2 (TCF7L2) gene is associated with type 2 diabetes. Evaluation of such associations in independent samples provides necessary replication and a robust assessment of effect size. Using four TCF7L2 single nucleotide polymorph...

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Bibliographic Details
Main Authors: Groves, C, Zeggini, E, Minton, J, Frayling, T, Weedon, M, Rayner, N, Hitman, G, Walker, M, Wiltshire, S, Hattersley, A, McCarthy, M
Format: Journal article
Language:English
Published: 2006